Construction and validation of a seven-gene signature for predicting overall survival in patients with kidney renal clear cell carcinoma via an integrated bioinformatics analysis.

Animal Cells and Systems
Huiming JiangNanHui Chen

Abstract

Kidney renal clear cell carcinoma (KIRC) remains a significant challenge worldwide because of its poor prognosis and high mortality rate, and accurate prognostic gene signatures are urgently required for individual therapy. This study aimed to construct and validate a seven-gene signature for predicting overall survival (OS) in patients with KIRC. The mRNA expression profile and clinical data of patients with KIRC were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC). Prognosis-associated genes were identified, and a prognostic gene signature was constructed. Then, the prognostic efficiency of the gene signature was assessed. The results obtained using data from the TCGA were validated using those from the ICGC and other online databases. Gene set enrichment analyses (GSEA) were performed to explore potential molecular mechanisms. A seven-gene signature (PODXL, SLC16A12, ZIC2, ATP2B3, KRT75, C20orf141, and CHGA) was constructed, and it was found to be effective in classifying KIRC patients into high- and low-risk groups, with significantly different survival based on the TCGA and ICGC validation data set. Cox regression analysis revealed that the seven-gene signature had an independ...Continue Reading

References

Feb 28, 1997·Statistics in Medicine·R Tibshirani
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·P TomassettiL Gullo
Jul 12, 2005·The Journal of Clinical Investigation·Nitish R MahapatraSushil K Mahata
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Nov 14, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew J Vickers, Elena B Elkin
Oct 13, 2007·Critical Reviews in Oncology/hematology·John S LamRobert A Figlin
Oct 29, 2010·European Urology·Juan I Martínez-SalamancaUNKNOWN International Renal Cell Carcinoma-Venous Thrombus Consortium
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Apr 19, 2015·Breast Cancer Research : BCR·Kimberly A SnyderKelly M McNagny
Oct 2, 2015·The Journal of Clinical Investigation·Pingping ZhuZusen Fan
Nov 6, 2015·Computational and Mathematical Methods in Medicine·Yueping ZhanLiucun Zhu
Dec 29, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Olivier DuvergerMaria I Morasso
Apr 17, 2018·Cell·Thomas J MitchellUNKNOWN TRACERx Renal Consortium
Nov 13, 2018·Journal of Cellular Physiology·Liang ChenYu Xiao
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 2, 2019·Journal of Cellular Physiology·Ming-Hui ZengXue-Hua Zhang
Apr 10, 2019·Computational and Structural Biotechnology Journal·Jee Soo ParkWon Sik Ham
Jun 14, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Qiufeng PanBing Li
Nov 20, 2019·International Journal of Molecular Sciences·Fuyan HuXiaoping Liu

❮ Previous
Next ❯

Citations

Jul 10, 2021·Signal Transduction and Targeted Therapy·Ruixue Huang, Ping-Kun Zhou

❮ Previous
Next ❯

Software Mentioned

SPSS
GSEA
GraphPad
R package survival
survminer
R package survivalROC
GraphPad Prism
R package DESeq2
R

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.