Construction, mechanism, and antibacterial resistance insight into polypeptide-based nanoparticles

Biomaterials Science
Jian-Bin ZhenKe-Wu Yang

Abstract

The emergence of drug-resistant bacteria poses a serious threat to public health. The traditional antibiotics have specific intracellular targets and disinfect via chemical ways, which easily lead to the development of drug resistance, therefore, cationic peptides as promising antibiotic agents have attracted extensive attention due to their unique properties. Herein, we report a class of amphiphilic peptide-based pectinate polymers with primary amino groups. The polymers spontaneously self-assembled into the positively charged nanoparticles, which were evaluated and confirmed by scanning electron microscopy (SEM) and dynamic light scattering (DLS). Biological assays revealed that the nanoparticles showed broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative bacteria, exhibiting a MIC of 16 μg mL-1 against six clinical bacteria, namely, E. faecalis, S. aureus, MRSA, VRE, P. aeruginosa, and K. pneumonia, and three bacterial strains E. coli and E. coli producing NDM-1 and ImiS, and showed a sterilization rate of 95.6% and 94.7% on S. aureus and E. coli, respectively. Importantly, the nanoparticles did not result in drug-resistance for both the normal and drug-resistant bacteria tested after 14 passage...Continue Reading

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Citations

Sep 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yueming WuRunhui Liu
Aug 7, 2020·Biomaterials Science·Qinggele Borjihan, Alideertu Dong
Nov 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanliang DongAnjie Dong
Jun 8, 2021·Biomaterials Science·Zixian CuiRachel A Letteri
Aug 14, 2020·Biomacromolecules·Pedro Salas-AmbrosioColin Bonduelle

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Methods Mentioned

BETA
chip
Surface Plasmon Resonance
NMR

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Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

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Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.