Construction of a diverse set of terpenoid decalin subunits from a common enantiomerically pure scaffold obtained by a biomimetic cationic cyclization

Chemical Communications : Chem Comm
Raquel FontanedaFélix Rodríguez

Abstract

An unprecedented biomimetic cationic cyclization reaction of an alkyne-containing geraniol-derived epoxide is used for the stereoselective synthesis of a novel enantiomerically pure scaffold that is easily transformed into a set of structurally diverse decalin derivatives with potential application in the synthesis of targeted natural products and/or natural-product-inspired new molecules.

References

Feb 18, 1976·Journal of the American Chemical Society·W S JohnsonB W Metcalf
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E E van Tamelen, D L Faler
Apr 14, 2007·The Journal of Organic Chemistry·Steven V Ley, Alessandra Polara
May 16, 2012·Journal of the American Chemical Society·Darryl D DixonPhil S Baran
Jul 19, 2013·Organic & Biomolecular Chemistry·José A González-DelgadoAlejandro F Barrero
Apr 15, 2015·Journal of the American Chemical Society·Goreti Rajendar, E J Corey
Jun 4, 2015·Angewandte Chemie·Shuji YamashitaMasahiro Hirama
Jul 8, 2017·Chemistry : a European Journal·Pedro AlonsoFélix Rodríguez

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Citations

Jan 7, 2022·Chemical Communications : Chem Comm·Olaya García-Pedrero, Félix Rodríguez

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