Construction of a Nomogram Based on a Hypoxia-Related lncRNA Signature to Improve the Prediction of Gastric Cancer Prognosis

Frontiers in Genetics
Qian ChenKaihua Chen

Abstract

Gastric cancer is one of the most common malignant tumors and has a poor prognosis. Hypoxia is related to the poor prognosis of cancer patients. We searched for hypoxia-related long non-coding RNAs (lncRNAs) to predict both overall survival (OS) and disease-free survival (DFS) of gastric cancer patients. We obtained hypoxia-related lncRNA expression profiles and clinical follow-up data of patients with gastric cancer from The Cancer Genome Atlas and the Molecular Signatures Database. The patients were randomly divided into a training group, test group and combined group. The hypoxia-related prognostic signature was constructed by Lasso regression and Cox regression models, the prognoses in different groups were compared by Kaplan-Meier (K-M) analysis, and the accuracy of the prognostic model was assessed by receiver operating characteristic (ROC) analysis. A hypoxia-related prognostic signature comprising 10 lncRNAs was constructed to predict both OS and DFS in gastric cancer. In the training, test and combined groups, patients were divided into high- and low-risk groups according to the formula. Kaplan-Meier analysis showed that patients in the high-risk group have poor prognoses, and the difference was significant in the subg...Continue Reading

References

Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexia IasonosKatherine S Panageas
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Oct 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin Lu, Yibin Kang
Jan 1, 2014·European Urology·Elena S Martens-UzunovaGeorge A Calin
Jan 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan HalabiEric J Small
Jan 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wenhua LiangJianxing He
Apr 8, 2015·The Lancet Oncology·Vinod P BalachandranRonald P DeMatteo
Nov 26, 2015·World Journal of Gastroenterology : WJG·Shikha Satendra SinghAlan Prem Kumar
Jan 7, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Kyung Hak ChoiBeom Su Kim
Jun 29, 2016·Cytokine·Jan PencikLukas Kenner
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei Peng, Airen Jiang
Jun 4, 2017·Molecular and Cellular Endocrinology·Bernd Groner, Viktoria von Manstein
Jul 14, 2017·Cancer Research·Arunoday BhanSubhrangsu S Mandal
Aug 4, 2018·Journal of Cellular Biochemistry·Peng Cheng
Dec 19, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Zhe Wang, Baoli Qin
Jun 28, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bang-Li HuJian-Wen Xu
Aug 7, 2019·Therapeutic Advances in Gastroenterology·Chaoran YuMinhua Zheng
Aug 17, 2019·Life Sciences·Hongkai LianChunyan Zhang
Oct 22, 2019·Frontiers in Genetics·Hui ZhangJifeng Feng
Dec 4, 2019·International Journal of Oncology·Yuta NakanoKazuma Kishi

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Datasets Mentioned

BETA
GSE84426

Methods Mentioned

BETA
RNA-seq
chip

Software Mentioned

GSEA
ENSEMBL
Formula
R package “ WGCNA ”
glmnet
limma
R package “ clusterProfiler ”
TIMER
Hmisc
R

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