Construction of a transplantable tissue-engineered artificial peritoneum

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
H KugaM Katano

Abstract

Peritoneal defects lead to serious postoperative problems. Thus the development of physiological material to cover peritoneal defects is very desirable. The aim of this study was to develop a transplantable artificial peritoneum. The artificial peritoneum consisted of collagen gel, fibroblasts, and mesothelial cells, and histological features were analyzed. The artificial peritoneum at the site of a peritoneal defect in the rat was transplanted to the abdominal wall. Histological examination revealed that the artificial peritoneum consisted of a flat mesothelial monolayer upon a stromal matrix. All transplanted artificial peritoneums adapted well to the host and prevented severe adhesion. Our artificial peritoneum may be a useful transplantable bioengineered material for repair of surgical peritoneal defects.

Citations

Feb 3, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christoph BrochhausenC James Kirkpatrick
May 7, 2011·Journal of Biomedical Materials Research. Part a·Christoph BrochhausenC James Kirkpatrick
Sep 1, 2016·Pleura and Peritoneum·Kunio Kawanishi
Jun 12, 2009·Cutaneous and Ocular Toxicology·Chris J SompsGareth Phillips
Jul 14, 2007·The International Journal of Artificial Organs·S E Herrick, S E Mutsaers
Jul 14, 2007·The International Journal of Artificial Organs·N Di PaoloG Garosi
Jul 14, 2007·The International Journal of Artificial Organs·C Ronco
Jul 14, 2007·The International Journal of Artificial Organs·P A Lucas

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