Construction of an upconversion nanoprobe with few-atom silver nanoclusters as the energy acceptor

Angewandte Chemie
Yan XiaoZhihong Liu

Abstract

Herein we report that few-atom silver nanoclusters (Ag NCs) can be effective energy acceptors for upconversion phosphors (UCPs). A luminescence resonance energy transfer (LRET) probe for biothiols was constructed by decorating UCPs with dithiol-stabilized Ag NCs. Owing to the unique properties of ultrasmall NCs, properties which bridge the gap between those of small molecules and those of nanoparticles, the use of approximately 1.9 nm Ag NCs as energy acceptors endows the probe with high energy-transfer efficiency, good biocompatibility, and flexibility. The UCP-Ag NC nanoprobe enables rapid and robust target assay in solutions. It was also uploaded into living cells and used to detect intracellular biothiol levels with high discrimination. Moreover, the probe shows transportability in vivo and can be used for tissue imaging. The facile growth of few-atom metal NCs on diverse templates may enable the development of various nanoprobes combining UCPs and metal NCs.

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Citations

Jan 21, 2016·Analytical Chemistry·Mengyuan HeZhihong Liu
Aug 20, 2015·Journal of the American Chemical Society·Zhen LiZhihong Liu
Jan 23, 2016·Chemical Communications : Chem Comm·Fei XuHong-Yuan Chen
Aug 30, 2017·Chemical Society Reviews·Jia WenShiguo Sun
Sep 12, 2015·Angewandte Chemie·Xiyan LiXiaogang Liu
Apr 13, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Chen WangPiaoping Yang
May 26, 2017·Chemical Communications : Chem Comm·Xinping LiuXiaogang Qu
Dec 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Puneet Khandelwal, Pankaj Poddar
May 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bing ChenFeng Wang
Jul 9, 2017·Analytical and Bioanalytical Chemistry·Hans H Gorris, Ute Resch-Genger
Jan 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qingxin HanWeisheng Liu
Feb 6, 2021·The Analyst·Chunning Sun, Michael Gradzielski
May 11, 2021·Chemical Communications : Chem Comm·Shuyang ZhaiZhihong Liu
Jul 21, 2021·Chemical Reviews·W Russ AlgarHyungki Kim
Dec 19, 2017·ACS Applied Materials & Interfaces·Bin GuQichun Zhang

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