Construction of analysis suitable vascular models using axis-aligned polycubes

Journal of Biomechanical Engineering
Adam UpdegroveNathan Wilson

Abstract

Image-based modeling is an active and growing area of biomedical research that utilizes medical imaging to create patient-specific simulations of physiological function. Under this paradigm, anatomical structures are segmented from a volumetric image, creating a geometric model that serves as a computational domain for physics-based modeling. A common application is the segmentation of cardiovascular structures to numerically model blood flow or tissue mechanics. The segmentation of medical image data typically results in a discrete boundary representation (surface mesh) of the segmented structure. However, it is often desirable to have an analytic representation of the model, which facilitates systematic manipulation. For example, the model then becomes easier to union with a medical device, or the geometry can be virtually altered to test or optimize a surgery. Furthermore, to employ increasingly popular isogeometric analysis methods the parameterization must be analysis suitable. Converting a discrete surface model to an analysis suitable model remains a challenge, especially for complex branched structures commonly encountered in cardiovascular modeling. To address this challenge, we present a framework to convert discrete ...Continue Reading

References

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Dec 7, 2007·Journal of Biomechanics·A Pérez del PalomarM Doblaré
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May 15, 2007·Computer Methods in Applied Mechanics and Engineering·Yongjie ZhangThomas J R Hughes
Jul 13, 2013·IEEE Transactions on Visualization and Computer Graphics·Bo LiHong Qin
Nov 20, 2016·International Journal for Numerical Methods in Biomedical Engineering·Jessica M OakesIrene E Vignon-Clementel
Dec 10, 2016·Annals of Biomedical Engineering·Adam UpdegroveShawn C Shadden

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