Construction of protein-modified TiO2 nanoparticles for use with ultrasound irradiation in a novel cell injuring method

Bioorganic & Medicinal Chemistry Letters
Chiaki OginoNobuaki Shimizu

Abstract

Recently, our group discovered an alternative titanium dioxide (TiO(2)) activation method that uses ultrasound irradiation (US/TiO(2)) instead of ultraviolet irradiation. The pre-S1/S2 protein from hepatitis B virus, which recognizes liver cells, was immobilized to the surface of TiO(2) nanoparticles using an amino-coupling method. The ability of the protein-modified TiO(2) nanoparticles to recognize liver cells was confirmed by surface plasmon resonance analysis and immuno-staining analyses. After uptake of TiO(2) nanoparticles by HepG2 cancer cells, the cells were injured using this US/TiO(2) method; significant cell injury was observed at an ultrasound irradiation intensity of 0.4 W/cm(2). Together with these results, this strategy could be applied to new cell injuring systems that use ultrasound irradiation in place of photodynamic therapy in the near future.

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Citations

Apr 11, 2014·Ultrasonics Sonochemistry·Kazuaki NinomiyaNobuaki Shimizu
Oct 25, 2011·Ultrasonics Sonochemistry·Kazuaki NinomiyaNobuaki Shimizu
Oct 21, 2015·Advanced Drug Delivery Reviews·Masaharu Somiya, Shun'ichi Kuroda
Sep 20, 2015·Ultrasonics Sonochemistry·Kazuaki NinomiyaNobuaki Shimizu
Aug 10, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Arno WieheMathias O Senge
Mar 30, 2017·Nanoscale Research Letters·Janusz BogdanJoanna Zarzyńska
Mar 2, 2013·Physical Chemistry Chemical Physics : PCCP·Zi Fei YinYong Hua Su
Feb 2, 2021·Biomaterials Science·Lihong SunLigang Cui
May 14, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jaime Andres Garcia DiosaRuben Jesus Camargo Amado

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