Consumer use and response to online third-party raw DNA interpretation services

Molecular Genetics & Genomic Medicine
Catharine WangJames J Cummings

Abstract

With the availability of raw DNA generated from direct-to-consumer (DTC) testing companies, there has been a proliferation of third-party online services that are available to interpret the raw data for both genealogy and/or health purposes. This study examines the current landscape and downstream clinical implications of consumer use of third-party services. Study participants were recruited online from social media platforms. A total of 321 survey respondents reported using third-party services for raw DNA interpretation. Participants were highly motivated to explore raw DNA for ancestral information (67%), individual health implications (62%), or both (40%). Participants primarily used one of seven companies to interpret raw DNA; 73% used more than one. Company choice was driven by the type of results offered (51%), price (45%), and online reviews (31%). Approximately 30% of participants shared results with a medical provider and 21% shared with more than one. Outcomes of sharing ranged from disinterest/discounting of the information to diagnosis of genetic conditions. Participants were highly satisfied with their decision to analyze raw DNA (M = 4.54/5), yet challenges in understanding interpretation results were reported i...Continue Reading

References

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Dec 6, 2011·Nucleic Acids Research·Michael Cariaso, Greg Lennon
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Citations

Feb 8, 2018·Journal of Genetic Counseling·Sarah C Nelson, Stephanie M Fullerton
Feb 23, 2019·Translational Behavioral Medicine·Erin Turbitt, Barbara B Biesecker
Mar 13, 2019·Journal of Genetic Counseling·Johanna L SchmidtSharon Reid Altmeyer
Jun 7, 2019·Molecular Diagnosis & Therapy·Susanne B Haga
Dec 31, 2019·AJOB Empirical Bioethics·Jacqueline SavardAinsley J Newson
Sep 30, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kevin M BowlingGregory M Cooper
Jul 13, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Tia MoscarelloErin Demo
Aug 14, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Christi J GuerriniAmy L McGuire
Aug 14, 2020·Journal of Community Genetics·Caryn Kseniya RubanovichCinnamon S Bloss
Aug 1, 2020·Annual Review of Medicine·Mary A MajumderAmy L McGuire
Feb 8, 2021·Journal of Genetic Counseling·Sarah BurkeMeagan Kaulfus
Jun 12, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Lauren N GalbraithKurt D Christensen
Jul 20, 2021·European Journal of Human Genetics : EJHG·Larissa PeckJehannine Austin

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