Consuming sucrose solution promotes leptin resistance and site specifically modifies hypothalamic leptin signaling in rats.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ruth B S Harris

Abstract

Rats consuming 30% sucrose solution and a sucrose-free diet (LiqS) become leptin resistant, whereas rats consuming sucrose from a formulated diet (HS) remain leptin responsive. This study tested whether leptin resistance in LiqS rats extended beyond a failure to inhibit food intake and examined leptin responsiveness in the hypothalamus and hindbrain of rats offered HS, LiqS, or a sucrose-free diet (NS). Female LiqS Sprague-Dawley rats initially only partially compensated for the calories consumed as sucrose, but energy intake matched that of HS and NS rats when they were transferred to calorimetry cages. There was no effect of diet on energy expenditure, intrascapular brown fat tissue (IBAT) temperature, or fat pad weight. A peripheral injection of 2 mg of leptin/kg on day 23 or day 26 inhibited energy intake of HS and NS but not LiqS rats. Inhibition occurred earlier in HS rats than in NS rats and was associated with a smaller meal size. Leptin had no effect on energy expenditure but caused a transient rise in IBAT temperature of HS rats. Leptin increased the phosphorylation of signal transducer and activator of transcription 3 (pSTAT3) in the hindbrain and ventromedial hypothalamus of all rats. There was a minimal effect of l...Continue Reading

References

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Feb 6, 2019·American Journal of Physiology. Endocrinology and Metabolism·Ruth B S Harris

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Methods Mentioned

BETA
transgenic

Key Resources (RRID) Mentioned

AB_2213764
AB_2313567

Software Mentioned

Statistica

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