Consumption of a functional fermented milk containing collagen hydrolysate improves the concentration of collagen-specific amino acids in plasma

Journal of Agricultural and Food Chemistry
Stephane WalrandTaous Lassel

Abstract

Clinical studies have shown that collagen hydrolysate (CH) may be able to protect joints from damage, strengthen joints, and reduce pain from conditions like osteoarthritis. CH is a collection of amino acids and bioactive peptides, which allows for easy absorption into the blood stream and distribution in tissues. However, although various matrices have been studied, the absorption of specific amino acids from CH added to a fresh fermented milk product (FMP) was not studied. The primary objective of the present study was to compare the plasma concentrations of four representative amino acids from the CH (glycine, proline, hydroxyproline, and hydroxylysine) contained in a single administration of a FMP with that of a single administration of an equal amount of neat hydrolyzed collagen. These four amino acids were chosen because they have already been used as markers of CH absorption rate and bioavailability. This was a single-center, randomized open, and crossover study with two periods, which was performed in 15 healthy male subjects. The subjects received randomly and in fasted state a single dose of product 1 (10 g of CH in 100 mL of FMP) and product 2 (10 g of CH dissolved in 100 mL of water) separated by at least 5 days. Af...Continue Reading

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Citations

Jul 25, 2015·Journal of Veterinary Pharmacology and Therapeutics·F ComblainY Henrotin
May 16, 2015·Critical Reviews in Food Science and Nutrition·Audrey DaneaultYohann Wittrant
Apr 24, 2012·Osteoarthritis and Cartilage·J P J Van VijvenS M A Bierma-Zeinstra
Jan 24, 2015·Journal of Biomaterials Applications·Shih-Bin LinHui-Huang Chen
Feb 9, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Denise ZdzieblikDaniel König
Feb 13, 2009·International Journal of Food Sciences and Nutrition·P Benito-RuizL A Zurita-Gavilanes
Jun 22, 2013·Experimental Biology and Medicine·Anita HartogJohan Garssen
Apr 23, 2020·Animals : an Open Access Journal From MDPI·Hasan GencogluKazim Sahin
Nov 23, 2021·International Journal of Sport Nutrition and Exercise Metabolism·Dana M LisKeith Baar

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