Consumption of a High-Fat Diet Alters Perineuronal Nets in the Prefrontal Cortex

Neural Plasticity
Paige M DingessTravis E Brown

Abstract

A key factor in the development of obesity is the overconsumption of fatty foods, which, in addition to facilitating weight gain, alters neuronal structures within brain reward circuitry. Our previous work demonstrates that sustained consumption of a high-fat diet (HFD) attenuates spine density in the prefrontal cortex (PFC). Whether HFD promotes structural adaptation among inhibitory cells of the PFC is presently unknown. One structure of interest is the perineuronal net (PNN), a specialized extracellular matrix surrounding, primarily, parvalbumin-containing GABAergic interneurons. PNNs contribute to synaptic stabilization, protect against oxidative stress, regulate the ionic microenvironment within cells, and modulate regional excitatory output. To examine diet-induced changes in PNNs, we maintained rats on one of three dietary conditions for 21 days: ad libitum chow, ad libitum 60% high fat (HF-AL), or limited-access calorically matched high fat (HF-CM), which produced no significant change in weight gain or adiposity with respect to chow controls. The PNN "number" and intensity were then quantified in the prelimbic (PL-PFC), infralimbic (IL-PFC), and ventral orbitofrontal cortex (OFC) using Wisteria floribunda agglutinin (W...Continue Reading

References

Sep 1, 1996·International Journal of Food Sciences and Nutrition·S A Gibson
Mar 3, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I Bautista-CastañoL Serra-Majem
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Jun 6, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jamie PetersPeter W Kalivas
Mar 23, 2012·Cell and Tissue Research·Difei Wang, James Fawcett
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jan-Harry CabungcalKim Q Do
Jan 24, 2014·Journal of Obesity·Stalo KarageorgiKazem Behbehani
Mar 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mike J F RobinsonCarrie R Ferrario
Mar 13, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan SlakerBarbara A Sorg
Feb 2, 2016·Biological Psychiatry·Robyn Mary BrownPeter William Kalivas
Mar 2, 2016·Biological Research·Cuauhtemoc Sandoval-SalazarMartha Silvia Solís-Ortiz
Mar 18, 2016·Brain Structure & Function·Paige M DingessTravis E Brown
Aug 31, 2016·Patient Preference and Adherence·Mark LemstraJohn Moraros
Jan 4, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer L ThompsonStephanie L Borgland
Mar 16, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paige M DingessTravis E Brown

❮ Previous
Next ❯

Software Mentioned

Zen imaging
ImageJ
GraphPad
Prism

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.