Consumption of Buglossoides arvensis seed oil is safe and increases tissue long-chain n-3 fatty acid content more than flax seed oil - results of a phase I randomised clinical trial

Journal of Nutritional Science
Natalie LefortMarc E Surette

Abstract

Enrichment of tissues with ≥20-carbon n-3 PUFA like EPA is associated with positive cardiovascular outcomes. Stearidonic acid (SDA; 18 : 4n-3) and α-linolenic acid (ALA; 18 : 3n-3) are plant-derived dietary n-3 PUFA; however, direct comparisons of their impact on tissue n-3 PUFA content are lacking. Ahiflower(®) oil extracted from Buglossoides arvensis seeds is the richest known non-genetically modified source of dietary SDA. To investigate the safety and efficacy of dietary Ahiflower oil, a parallel-group, randomised, double-blind, comparator-controlled phase I clinical trial was performed. Diets of healthy subjects (n 40) were supplemented for 28 d with 9·1 g/d of Ahiflower (46 % ALA, 20 % SDA) or flax seed oil (59 % ALA). Blood and urine chemistries, blood lipid profiles, hepatic and renal function tests and haematology were measured as safety parameters. The fatty acid composition of fasting plasma, erythrocytes, polymorphonuclear cells and mononuclear cells were measured at baseline and after 14 and 28 d of supplementation. No clinically significant changes in safety parameters were measured in either group. Tissue ALA and EPA content increased in both groups compared with baseline, but EPA accrual in plasma and in all cel...Continue Reading

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Citations

Mar 2, 2018·Journal of Applied Microbiology·A Novinscak, M Filion
Aug 11, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pekka MäättänenPhilip M Sherman
Jan 17, 2020·Molecular Nutrition & Food Research·Pekka MäättänenPhilip M Sherman
May 21, 2020·Critical Reviews in Food Science and Nutrition·P PrasadR V Sreedhar
Apr 27, 2021·Journal of Environmental Management·Mohammad Said ChmitTill Beuerle

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Methods Mentioned

BETA
blood draw
blood draws

Clinical Trials Mentioned

NCT02226354

Software Mentioned

R

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