Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study

Nutrition Journal
Meri P NantzSusan S Percival

Abstract

Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms. The study was a randomized, double-blind, placebo-controlled, parallel intervention. Subjects drank a low calorie cranberry beverage (450 ml) made with a juice-derived, powdered cranberry fraction (n = 22) or a placebo beverage (n = 23), daily, for 10 wk. PBMC were cultured for six days with autologous serum and PHA-L stimulation. Cold and influenza symptoms were self-reported. The proliferation index of γδ-T cells in culture was almost five times higher after 10 wk of cranberry beverage consumption (p <0.001). In the cranberry beverage group, the incidence of illness was not reduced, however significantly fewer symptoms of illness were reported (p = 0.031). Consumption of the cranberry beverage modified the ex vivo proliferation of γδ-T cells. As these cells are located in the epithelium and serve as a first line of defense, improving their function may be related to reducing the number of symptoms associated with a cold and flu.

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Citations

Nov 17, 2015·Expert Review of Anti-infective Therapy·Roodabeh BahramsoltaniNima Rezaei
Apr 2, 2016·Research in Veterinary Science·Andrew R WilliamsStig M Thamsborg
Jul 15, 2015·Clinical Epigenetics·Christian BuschSascha Venturelli
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Apr 9, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Haider Abdul-Lateef Mousa
Jul 11, 2020·Critical Reviews in Food Science and Nutrition·Ellen José van der Gaag, Thalia Zoe Hummel
Jan 15, 2016·The Journal of Nutrition·Susan S Percival
Jun 12, 2020·International Journal of Molecular Sciences·Paola ChecconiLucia Nencioni
Jun 17, 2020·The American Journal of Chinese Medicine·Yan-Xi ZengYi-Han Chen
Jan 26, 2021·Frontiers in Veterinary Science·Mahmoud AlagawanyMohamed E Abd El-Hack
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Jul 11, 2021·Neuroscience and Biobehavioral Reviews·Giuseppe AnnunziataSeyed Mohammad Nabavi

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Methods Mentioned

BETA
blood draw
blood collection
flow cytometry
ELISA
blood draws

Software Mentioned

FlowJo Analysis
JMP
SOFTmax® Pro
CellQuest Pro
xPONENT

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