Consumption of Honey, Sucrose, and High-Fructose Corn Syrup Produces Similar Metabolic Effects in Glucose-Tolerant and -Intolerant Individuals

The Journal of Nutrition
Susan K RaatzMatthew J Picklo

Abstract

Public health recommendations call for a reduction in added sugars; however, controversy exists over whether all nutritive sweeteners produce similar metabolic effects. The objective was to compare the effects of the chronic consumption of 3 nutritive sweeteners [honey, sucrose, and high-fructose corn syrup containing 55% fructose (HFCS55)] on circulating glucose, insulin, lipids, and inflammatory markers; body weight; and blood pressure in individuals with normal glucose tolerance (GT) and those with impaired glucose tolerance (IGT). In a crossover design, participants consumed daily, in random order, 50 g carbohydrate from assigned sweeteners for 2 wk with a 2- to 4-wk washout period between treatments. Participants included 28 GT and 27 IGT volunteers with a mean age of 38.9 ± 3.6 y and 52.1 ± 2.7 y, respectively, and a body mass index (in kg/m(2)) of 26 ± 0.8 and 31.5 ± 1.0, respectively. Body weight, blood pressure (BP), serum inflammatory markers, lipids, fasting glucose and insulin, and oral-glucose-tolerance tests (OGTTs) were completed pre- and post-treatment. The OGTT incremental areas under the curve (iAUCs) for glucose and insulin were determined and homeostasis model assessment of insulin resistance (HOMA-IR) score...Continue Reading

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Oct 7, 2016·British Medical Bulletin·Michael E J Lean, Lisa Te Morenga
Nov 12, 2019·The American Journal of Clinical Nutrition·Lukas SchwingshacklSabrina Schlesinger
Aug 18, 2020·Critical Reviews in Food Science and Nutrition·Edward Archer, Bahram Arjmandi
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Jul 6, 2021·The British Journal of Nutrition·Zohreh GholamiNasrin Nasimi
Nov 30, 2021·Nutrition and Health·Regis C PearsonNathan T Jenkins

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