Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial

Food & Function
Antonio González-SarríasJuan C Espín

Abstract

Gut microbiota dysbiosis alters the intestinal barrier function, increases plasma lipopolysaccharide (LPS) levels, which promotes endotoxemia, and contributes to the onset and development of colorectal cancer (CRC). We report here for the first time the reduction of plasma LPS-binding protein (LBP) levels, a marker of endotoxemia, after pomegranate consumption in newly diagnosed CRC patients.

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Citations

Mar 21, 2020·Molecular Nutrition & Food Research·Adrián Cortés-MartínJuan Carlos Espín
Jun 21, 2020·Genes & Nutrition·N Vázquez-ManjarrezC Manach
Nov 22, 2019·Anti-cancer Agents in Medicinal Chemistry·Rumana AhmadArvind K Srivastava
Dec 10, 2020·Journal of Gastroenterology and Hepatology·Sedigheh Taghinezhad-SXiangsheng Fu
Aug 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Priyankar Dey
Oct 27, 2021·Phytotherapy Research : PTR·Zohre SenobariKhadijeh Jamialahmadi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays

Clinical Trials Mentioned

NCT01916239

Software Mentioned

SPSS
Sigma Plot

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