Consumption of the epidermis in acral lentiginous melanoma

Journal of Cutaneous Pathology
Chika OhataIchiro Katayama

Abstract

Consumption of the epidermis (hereafter, consumption), namely thinning of the epidermis with attenuation of basal and suprabasal layers and loss of rete ridges adjacent to collections of melanocytes, has been used to differentiate invasive melanoma from Spitz nevi. Evaluation of 213 invasive melanomas, including only two cases of acral lentiginous melanoma (ALM), showed that the frequency of consumption increases with increasing tumor thickness. We evaluated consumption in 52 acral melanomas relative to age, gender, Breslow depth, tumor thickness (based on the 2010 American Joint Commission on Cancer guidelines), Clark level, mitoses, ulceration, vertical-growth phase, regression, tumor-infiltrating lymphocytes and anatomical site. Consumption was more frequent in ALM with increasing Breslow depth (p = 0.01), and in the presence of ulceration (p = 0.0078); in all cases with ulcer, consumption was found adjacent to the ulceration. There was no statistically significant difference in consumption in nail melanomas in comparison to melanomas of acral skin other than the nail. These results support the hypothesis that epidermal thinning in consumption represents an early phase of ulceration. No statistically significant difference i...Continue Reading

References

Jun 1, 1992·The American Journal of Dermatopathology·J SmolleH Kerl
Aug 1, 1989·The American Journal of Dermatopathology·A B Ackerman
Dec 4, 2004·The American Journal of Surgical Pathology·Markus HantschkePhilip E LeBoit
Mar 1, 2008·International Journal of Clinical Oncology·Kazuyuki IshiharaUNKNOWN Prognosis and Statistical Investigation Committee of the Japanese Skin Cancer Society
May 28, 2010·Journal of Cutaneous Pathology·F Stephen Hodi, Glenn Dranoff
Mar 10, 2011·Journal of Cutaneous Pathology·Adriano PirisLyn M Duncan

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Citations

Apr 20, 2001·The Australasian Journal of Dermatology·K E ThaiR D Sinclair
Dec 17, 2014·Journal of the American Academy of Dermatology·Takaaki MatsumotoMasashi Akiyama
May 28, 2015·Journal of Cutaneous Pathology·Justin P BandinoDirk M Elston
Nov 3, 2017·The American Journal of Dermatopathology·Caroline Y WinslowCarlos H Nousari
Nov 13, 2014·American Journal of Clinical Pathology·Marie L Bønnelykke-BehrndtzTorben Steiniche

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