Contact activation of blood coagulation: trigger properties and hysteresis. Kinetic recognition of foreign surfaces upon contact activation of blood coagulation: a hypothesis

Journal of Theoretical Biology
A V Pokhilko, F I Ataullakhanov

Abstract

A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hysteretic manner. Within a range of relatively small signals, two (activated and non-activated) stable states coexist (bistability). Signals of the natural environment (surfaces of endothelial and blood cells) seem to be in the range of bistability; therefore, contact activation that persists for a short time can induce a transition of the system to the activated state, and, correspondingly, the formation of a clot. The system cannot return to the initial state, which is characterized by low activation levels, until the activating signals decrease significantly below those present in the circulation.

Citations

Jan 25, 2006·Pathophysiology of Haemostasis and Thrombosis·Fazoil I Ataullakhanov, Mikhail A Panteleev
Jan 27, 2009·Biomaterials·Erwin A Vogler, Christopher A Siedlecki
Apr 29, 2006·Biomaterials·Rui ZhuoErwin A Vogler
Aug 16, 2005·Biomaterials·Zhe GuoChristopher A Siedlecki
Jul 19, 2015·Journal of Theoretical Biology·Vladislava A TerentyevaMikhail A Panteleev
Jul 24, 2007·Biomaterials·Rui ZhuoErwin A Vogler
Apr 26, 2000·The Journal of Trauma·I HelttulaE Gullichsen
Mar 19, 2019·Journal of Biomaterials Applications·Ajinkya A ShitoleBaijayantimala Garnaik
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A Kramoroff, J M Nigretto
Aug 16, 2000·Thrombosis Research·A V Pokhilko

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