Contact allergy due to colophony (VII). Sensitizing studies with oxidation products of abietic and related acids

Contact Dermatitis
B M HausenE Budianto

Abstract

9 oxidation products of abietic acid, dehydroabietic acid, and levopimaric acid were prepared synthetically to determine their sensitizing potential in guinea pigs. It was found that compounds with epoxy and peroxo groups in rings A and B had a notable sensitizing potential. The same result was found with 7-oxode-hydroabietic acid identified earlier in rosin (3) and a polar fraction obtained from commercial abietic acid, suggesting the presence of still unidentified oxidation products. Hydroxylation of rings A or B, or conversion to the methyl esters, considerably decreases the sensitizing potential. A model is presented underlining the importance of hydrophobic and polar domains, in addition to chemically reactive groupings, in the allergen. Insertion into the lipid bilayer may play an important rôle in contact sensitivity.

References

Nov 1, 1979·The Journal of Clinical Investigation·V S ByersW L Epstein
Oct 1, 1985·Contact Dermatitis·A T KarlbergJ E Wahlberg
Jan 1, 1982·Archives of Dermatological Research·O Gabriel-RobezE Grosshans

❮ Previous
Next ❯

Citations

Jan 1, 1992·Archives of Dermatological Research·E GäfvertJ L Nilsson
Nov 13, 2004·International Archives of Occupational and Environmental Health·Johannes GeierWolfgang Uter
Dec 9, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·S SadhraI S Foulds
Jan 13, 1998·American Industrial Hygiene Association Journal·P A SmithK Still
Jan 5, 2000·Contact Dermatitis·A M Downs, J E Sansom
Jul 8, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Erin MatthysAlison Ehrlich
Aug 1, 1994·Contact Dermatitis·G FärmA T Karlberg
Jul 1, 2008·Regulatory Toxicology and Pharmacology : RTP·P A BothamTorbjorn Malmfors
Dec 3, 2003·Contact Dermatitis·Johannes GeierThomas Fuchs
Jul 1, 1997·Contact Dermatitis·F PereiraM H Lacerda
Nov 1, 1994·Contact Dermatitis·M BerghA T Karlberg
Oct 1, 1994·Contact Dermatitis·A T Karlberg
Apr 1, 1993·Contact Dermatitis·L P ShaoJ L Nilsson
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J ElmsA D Curran
Mar 7, 2008·Journal of Occupational and Environmental Hygiene·Katja HagströmKåre Eriksson
Feb 1, 1994·Contact Dermatitis·E Mallon, S M Powell
May 10, 2002·Contact Dermatitis·Jeanne Duus JohansenTorkil Menné

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.