Contact-Dependent Growth Inhibition Proteins in Acinetobacter baylyi ADP1

Current Microbiology
Eliana De GregorioPier Paolo Di Nocera

Abstract

Bacterial contact-dependent growth inhibition (CDI) systems are two-partner secretion systems in which toxic CdiA proteins are exported on the outer membrane by cognate transporter CdiB proteins. Upon binding to specific receptors, the C-terminal toxic (CT) domain, detached from CdiA, is delivered to neighbouring cells. Contacts inhibit the growth of not-self-bacteria, lacking immunity proteins co-expressed with CdiA, but promote cooperative behaviours in "self" bacteria, favouring the formation of biofilm structures. The Acinetobacter baylyi ADP1 strain features two CdiA, which differ significantly in size and have different CT domains. Homologous proteins sharing the same CT domains have been identified in A. baumannii. The growth inhibition property of the two A. baylyi CdiA proteins was supported by competition assays between wild-type cells and mutants lacking immunity genes. However, neither protein plays a role in biofilm formation or adherence to epithelial cells, as proved by assays carried out with knockout mutants. Inhibitory and stimulatory properties may be similarly uncoupled in A. baumannii proteins.

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Citations

May 1, 2019·Journal of Bacteriology·Jonathan P Allen, Alan R Hauser
Aug 28, 2020·Frontiers in Microbiology·Renatas KrasauskasEdita Sužiedėlienė
Jan 19, 2019·Scientific Reports·Eliana De GregorioPier Paolo Di Nocera
Dec 8, 2020·Frontiers in Microbiology·Hsiao-Han LinErh-Min Lai
Oct 31, 2020·International Journal of Molecular Sciences·Larisa N IkryannikovaAndrey A Zamyatnin
Jan 28, 2022·Journal of Cellular Physiology·Vaishali KaushikVishvanath Tiwari

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Methods Mentioned

BETA
genetic modifications
PCR

Software Mentioned

clustalW

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