Contact dermatitis caused by 2-HEMA and GM dentin primer solutions applied to guinea pigs and humans

Dental Materials Journal
K KatsunoT Yoshida

Abstract

The purposes of this study were to examine whether 2-HEMA, GM, and methacrylic acid cause contact dermatitis, and to determine the optimum concentrations of these primers for sensitization and challenge in guinea pigs. A sensitizing concentration of 0.2% 2-HEMA resulted in strong rubefaction and several vesiculopapules in response to the challenge, and a sensitizing concentration of 0.5% GM produced strong rubefaction at 24 hours. We also observed the development of contact dermatitis on human brachia in a closed-patch test. Skin that was treated with both 2-HEMA and GM clearly showed the onset of rubefaction and itchiness. 2-HEMA caused sensitized delayed allergic reactions at all the concentrations tested.

Citations

Oct 14, 2009·Dental Materials Journal·Kunio IkemuraTakeshi Endo
Nov 17, 2004·Journal of Oral Rehabilitation·Y TakahashiH Hisamitsu
Aug 12, 2009·Journal of Applied Oral Science : Revista FOB·Ho-Nam LimYong-Keun Lee
Feb 6, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Serge Bouillaguet
Apr 7, 2006·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Apr 7, 2006·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
May 13, 1998·Journal of Oral Rehabilitation·K KatsunoT Yoshida
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