Contact dermatitis due to rubber boots worn by Japanese farmers, with special attention to 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline (ETMDQ) sensitivity

Contact Dermatitis
K NishiokaM A Kaniwa

Abstract

An investigation was conducted as follows in 9 farmers with contact allergy due to rubber boots: (i) patch tests with 19 rubber additives; (ii) chemical analysis of additives in 6 pairs of rubber boots; (iii) use tests on a hypoallergenic trial product in 5 patients. The following results were obtained: (i) in the patch tests, all 9 patients showed positive reactions to 1 or more of the nitrogen(N)-containing antioxidants (IPPD, DMBPPD, ETMDQ); (ii) ETMDQ was detected in 1 pair of rubber boots, and IPPD and DMBPPD in another pair; (iii) no patient using hypoallergenic boots during rice-planting had recurrent dermatitis. N-containing antioxidants, such as IPPD, DMBPPD and ETMDQ, were thus considered as the main causative agents and the trial product was found useful for managing contact dermatitis. Contact allergy due to ETMDQ in rubber is reported here for the 1st time.

References

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Citations

Feb 24, 1998·Clinics in Dermatology·D Koh, C L Goh
Sep 16, 1998·The Australasian Journal of Dermatology·M Rademaker
May 10, 2002·Contact Dermatitis·A M van CoevordenP G M van der Valk
Jan 13, 2010·International Journal of Dermatology·Cynthia E IrbySteven R Feldman
Jul 8, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Erin MatthysAlison Ehrlich
Dec 30, 2016·Contact Dermatitis·Katharine L WarburtonMark Wilkinson

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