Contact Dermatitis to Medications and Skin Products

Clinical Reviews in Allergy & Immunology
Henry L Nguyen, James A Yiannias

Abstract

Consumer products and topical medications today contain many allergens that can cause a reaction on the skin known as allergic contact dermatitis. This review looks at various allergens in these products and reports current allergic contact dermatitis incidence and trends in North America, Europe, and Asia. First, medication contact allergy to corticosteroids will be discussed along with its five structural classes (A, B, C, D1, D2) and their steroid test compounds (tixocortol-21-pivalate, triamcinolone acetonide, budesonide, clobetasol-17-propionate, hydrocortisone-17-butyrate). Cross-reactivities between the steroid classes will also be examined. Next, estrogen and testosterone transdermal therapeutic systems, local anesthetic (benzocaine, lidocaine, pramoxine, dyclonine) antihistamines (piperazine, ethanolamine, propylamine, phenothiazine, piperidine, and pyrrolidine), topical antibiotics (neomycin, spectinomycin, bacitracin, mupirocin), and sunscreen are evaluated for their potential to cause contact dermatitis and cross-reactivities. Finally, we examine the ingredients in the excipients of these products, such as the formaldehyde releasers (quaternium-15, 2-bromo-2-nitropropane-1,3 diol, diazolidinyl urea, imidazolidinyl u...Continue Reading

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Citations

Feb 18, 2020·Expert Opinion on Drug Safety·Kayla Fourzali, Gil Yosipovitch
Apr 18, 2020·Pediatric Dermatology·Idy Tam, JiaDe Yu
Jul 4, 2020·Current Opinion in Pediatrics·Idy Tam, JiaDe Yu
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May 29, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Rebecca S KimyonErin M Warshaw
Aug 8, 2020·International Journal of Toxicology·Filipa A L S SilvaMaria T Cruz
Dec 23, 2020·Contact Dermatitis·Liesbeth GilissenAn Goossens
Oct 23, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kanwaljit K Brar
Aug 21, 2021·Dermatitis : Contact, Atopic, Occupational, Drug·Anton de Groot
Aug 31, 2021·The Journal of Dermatological Treatment·Leon H KircikBinu Alexander

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