PMID: 2497558Jan 1, 1989Paper

Contact hypersensitivity response to glutaraldehyde in guinea pigs and mice

Toxicology and Industrial Health
M L SternA E Munson

Abstract

Glutaraldehyde has a wide spectrum of uses which can result in dermal contact with the agent. The low number of reports of hypersensitive reactions to glutaraldehyde indicates a low incidence of sensitization. This paper describes the contact hypersensitivity response to glutaraldehyde in the guinea pig and the mouse. Female albino Hartley strain guinea pigs and female B6C3F1 mice were sensitized with 0.3, 1.0 and 3.0% glutaraldehyde and challenged with 10% glutaraldehyde. Doses of glutaraldehyde were selected from assays for primary irritancy. Guinea pigs received 100 microliters by direct dermal application, for 14 consecutive days, and mice received 20 microliters by direct dermal application, for 5 or 14 consecutive days, to sites prepared by shaving and dermabrading. Rest periods were 7 or 14 days for guinea pigs and 4 or 7 days for mice. Measurement of the contact hypersensitivity response in guinea pigs was both visual evaluation (scoring) at 24 and 48 hours following challenge and radioisotopic assay at 48 hours, and in mice by radioisotopic assay 48 hours after challenge. Both guinea pigs and mice demonstrated dose-dependent contact hypersensitivity responses to glutaraldehyde. The radioisotopic assay appeared to be mo...Continue Reading

References

Jan 1, 1975·International Archives of Allergy and Applied Immunology·M A VadasA Whitelaw
Jan 1, 1987·Annual Review of Immunology·J J WoodruffY H Chin
May 1, 1980·The Journal of Investigative Dermatology·H N Claman, S D Miller
Feb 1, 1980·The Journal of Investigative Dermatology·P R BergstresserJ W Streilein

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Citations

Jan 1, 1990·Archives of Dermatological Research·M L Stern, A E Muson
Feb 6, 1995·Toxicology·D M SailstadM K Selgrade
Apr 14, 2006·Journal of Occupational Health·Tomoko Takigawa, Yoko Endo
Jan 11, 1992·Critical Reviews in Toxicology·R O BeauchampF W Kari
Sep 1, 1989·Drug and Chemical Toxicology·M L SternA E Munson
Jan 1, 1991·Drug and Chemical Toxicology·M L SternA E Munson
Oct 9, 1999·Contact Dermatitis·H WahlkvistC Lidén
Dec 2, 2004·The Journal of Hospital Infection·K RideoutS M Kennedy
May 6, 2004·Toxicology and Applied Pharmacology·Shahla AzadiB Jean Meade
Dec 9, 2014·International Journal of Molecular Medicine·P-L LamC-H Chui
Feb 22, 2003·Surgical Infections·J L Sagripanti, A Bonifacino

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