Contact Lens-Induced Discomfort and Inflammatory Mediator Changes in Tears

Eye & Contact Lens
Simin MasoudiMark Willcox

Abstract

Studies indicate that contact lens (CL) discontinuation mostly occurs because of dryness and discomfort symptoms. This study aimed to investigate relationships between changes in the concentration of tear inflammatory mediators with subjective comfort ratings with CL wear and no contact lens wear between morning and evening. Forty-five subjects collected tears twice daily in the morning and in the evening with or without lenses. Comfort was rated subjectively on a scale from 1 to 100 (where 100 was extremely comfortable) just before each tear collection. Tear samples were assayed for complement components (C3 and C3a), leukotriene B4 (LTB4), secretory phospholipase A2 (sPLA2), secretory immunoglobulin A (sIgA), and bradykinin using commercially available immuno-based assay kits. Comfort ratings showed a statistically significant decline from morning to evening both with CL (89.0±10.1 AM vs. 76.7±15.2 PM; P<0.001) and without CL (89.1±10.2 AM vs. 84.2±12.6 PM; P<0.005) wear. The decline was steeper with lens wear (P<0.001). Bradykinin and sPLA2 levels did not change between morning and evening or with CL wear (P>0.05). Leukotriene B4 levels were slightly higher in CL (CL 43.4±12.6 pg/ml vs. No CL 39.4±13.4 pg/mL; P=0.034), where...Continue Reading

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Citations

Feb 1, 2017·Current Eye Research·Simin MasoudiMark Willcox
Aug 18, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Simin MasoudiMark D P Willcox
Dec 14, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nathan Efron
Jul 27, 2018·Investigative Ophthalmology & Visual Science·Laura E DownieAlgis J Vingrys
Oct 12, 2018·Eye & Contact Lens·Shyam PanthiJason J Nichols
May 24, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Mark Dp Willcox
Dec 5, 2019·Investigative Ophthalmology & Visual Science·Yong Woo JiHyung Keun Lee
Dec 22, 2016·Eye & Contact Lens·Mark D P Willcox
Sep 6, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nathan Efron, Philip B Morgan
Oct 11, 2019·Ocular Immunology and Inflammation·Alberto López-de la RosaMaría J González-García
Sep 17, 2020·Biomedicines·Dmitry V ChistyakovEvgeni Yu Zernii
Apr 10, 2019·Current Medicinal Chemistry·Alberto López-de la RosaAmalia Enríquez-de-Salamanca
May 4, 2020·The Ocular Surface·Becca A FlitterKarsten Gronert
Feb 4, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Melania OlivieriDario Rusciano
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Mark WillcoxLyndon Jones
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Fiona StapletonJames S Wolffsohn
Apr 8, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Padmapriya RamamoorthyJason J Nichols
Apr 14, 2021·Experimental Eye Research·Simin MasoudiMark D Willcox

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