Contact radiotherapy boost in association with 'watch and wait' for rectal cancer: initial experience and outcomes from a shared programme between a district general hospital network and a regional oncology centre

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
F M SmithA Sun Myint

Abstract

Recent data have highlighted the potential of more intensive neoadjuvant protocols to increase and sustain the rate of complete response in rectal cancer managed nonoperatively. This study aimed to review the outcome of all patients from our district general hospitals network who had received standard neoadjuvant therapy and were additionally referred to a centre of excellence for contact X-ray brachytherapy or high-dose-rate brachytherapy boost. A retrospective, chart-based review of all patients co-managed in this manner was performed. Patient details were retrieved from a prospectively maintained departmental database. Indications for treatment, patient outcome and serial data from follow-up clinical and radiological assessment were analysed. Seventeen patients treated over a 6-year period were identified. Median follow-up was 20 (5-54) months. Fourteen patients were clinically staged as T2 or T3 and eight were clinically node positive. Three patients died, of whom only one was initially a surgical candidate but refused an exenteration. Of the 14 patients who remain alive, 11 (79%) have a sustained complete (n = 8) or partial (n = 3) response. Two patients had an incomplete response, one is being palliated and the other awai...Continue Reading

References

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Citations

Feb 12, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F M SmithA Sun Myint
Sep 14, 2016·Annual Review of Medicine·Geerard L BeetsRegina G H Beets-Tan
Mar 28, 2018·BioMed Research International·Valentina LancellottaCynthia Aristei
Aug 28, 2020·World Journal of Gastroenterology : WJG·Fernando López-CamposFelipe Couñago

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