Contact sensitization of mice to nickel sulphate and potassium dichromate

Contact Dermatitis
I KimberJ Hilton

Abstract

The ability of nickel sulphate and potassium dichromate to induce contact sensitization in mice has been investigated. Topical exposure of mice to 0.5% potassium dichromate in dimethylsulphoxide (DMSO) under occlusion resulted in specific contact sensitization in each of 7 experiments. Although sensitization to nickel sulphate under the same conditions was weak and somewhat variable, evidence for significant levels of contact allergy was obtained in 4 of 7 experiments. In addition, repeated topical application of both nickel sulphate and potassium dichromate in DMSO was found to result in the induction of lymphocyte proliferative responses in lymph nodes draining the site of exposure. These data indicate that epicutaneous exposure to both metal salts may cause specific contact sensitization in mice.

References

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Citations

Oct 8, 1999·Journal of Applied Toxicology : JAT·R J DearmanI Kimber
Jun 1, 1992·Journal of Applied Toxicology : JAT·E W ScholesS J Waite
Nov 1, 1995·Journal of Applied Toxicology : JAT·C Boussiquet-LerouxD Holder
Apr 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P A BothamW J Bontinck
Jan 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D A Basketter, E W Scholes
Jun 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D A BasketterI Kimber
Nov 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y IkarashiA Nakamura
Sep 22, 1994·Toxicology·I KimberD A Basketter
Feb 1, 1991·Toxicology Letters·I KimberS J Waite
Jun 1, 1996·Journal of Pharmacological and Toxicological Methods·F L ClottensB Nemery
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C A RyanG F Gerberick
Jun 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Feb 13, 2003·Contact Dermatitis·Ian KimberG F Gerberick
Nov 12, 2010·Journal of Immunotoxicology·Ian KimberRebecca J Dearman
May 12, 2010·Journal of Dermatological Science·Pål JohansenThomas M Kündig
Jun 7, 2003·Cardiology Clinics·Silviu ItescuKatherine Lietz
Nov 15, 2018·Contact Dermatitis·Trine H PetersenCharlotte M Bonefeld
Mar 7, 2017·Frontiers in Immunology·Yasuo YoshiokaKen J Ishii

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