PMID: 3770977Jan 1, 1986Paper

Contact-sensitizing and tolerogenic properties of 2,4-dinitrothiocyanobenzene

International Archives of Allergy and Applied Immunology
I KimberS T Walsh

Abstract

Epicutaneous application of 2,4-dinitrothiocyanobenzene (DNTB) is said to result in specific immunological hyporesponsiveness and fails to induce contact sensitization. However, we demonstrate that topical exposure to DNTB causes activation of the draining lymph node in mice and the induction of contact sensitization in both rodents and a single human volunteer. In mice and rats, pre-exposure to DNTB failed to impair subsequent responsiveness to the cross-reactive allergen 2,4-dinitrochlorobenzene. These data provide evidence that DNTB cannot be regarded as an exclusive tolerogen when applied epicutaneously and indicate that attempts to define the characteristics of tolerising chemicals from analysis of this agent may be misleading.

Citations

Nov 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Kimber
Feb 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I Kimber, R J Dearman
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I KimberM H Beck
Feb 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
May 1, 1994·The Journal of Experimental Medicine·T A FergusonT S Griffith
Jan 1, 1996·Contact Dermatitis·D A BasketterI Kimber
Oct 15, 1990·Cellular Immunology·F Nanishi, J R Battisto
Nov 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris PickardPeter S Friedmann
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideki WatanabeOlivier Gaide
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helge RiemannStephan Grabbe

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