Contact System Activation and Neutrophil Extracellular Trap Markers: Risk Factors for Portal Vein Thrombosis in Patients With Hepatocellular Carcinoma

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Jong Do SeoHyun Kyung Kim

Abstract

Although portal vein thrombosis (PVT) commonly occurs in patients with hepatocellular carcinoma (HCC), the hypercoagulability mechanism in patients with HCC is not entirely clear. Recently, tumor-induced formation of neutrophil extracellular traps (NET) has been shown to trigger contact system activation, and contact system activation has been shown to be a new mechanism of thrombosis. Therefore, we investigated whether contact system activation and NET formation occurred in relation to PVT in HCC patients. The circulating levels of NET formation markers (DNA-histone complex, double-stranded DNA, neutrophil elastase) and contact system activation markers (factor XIIa and high-molecular-weight kininogen) were measured in 177 patients who had been diagnosed with HCC and 48 healthy controls. Presence of PVT was confirmed in 77 HCC patients. The levels of NET formation and contact system activation markers were significantly higher in patients than in healthy controls and they increased significantly with the increase in the model for end-stage liver disease (MELD) scores. Of note, these markers were significantly higher in HCC patients with PVT than in those without PVT. These NET formation markers and the contact system activatio...Continue Reading

References

Jan 4, 2003·Gastroenterology·Russell WiesnerUNKNOWN United Network for Organ Sharing Liver Disease Severity Score Committee
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen H CaldwellUNKNOWN Coagulation in Liver Disease Group
Jul 31, 2008·Journal of Thrombosis and Haemostasis : JTH·S A Smith, J H Morrissey
Aug 13, 2008·Current Opinion in Hematology·Felicitas Müller, Thomas Renné
Jan 28, 2010·The American Journal of Medicine·Sameer ParikhPrashant Kapoor
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Aug 2, 2011·Seminars in Thrombosis and Hemostasis·Coen MaasThomas Renné
Apr 23, 2014·International Journal of Laboratory Hematology·S de MaatC Maas
Jul 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Travis J GouldPatricia C Liaw
Oct 11, 2014·Journal of Gastroenterology and Hepatology·Seon Young KimHyun Kyung Kim
Dec 9, 2014·The New England Journal of Medicine·Harry R BüllerUNKNOWN FXI-ASO TKA Investigators
Feb 20, 2015·Hematology·Maurits L van Montfoort, Joost C M Meijers
May 6, 2015·Journal of Clinical and Experimental Hepatology·Yogesh K Chawla, Vijay Bodh
Dec 8, 2015·Hematology·Jody L Kujovich
Dec 29, 2015·Journal of Thrombosis and Haemostasis : JTH·Andrew T LongThomas Renné
Mar 2, 2017·International Journal of Molecular Sciences·Norbaini Abdol RazakPat Metharom

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Citations

Sep 10, 2020·Seminars in Thrombosis and Hemostasis·Fien A von Meijenfeldt, Craig N Jenne
Oct 13, 2020·Frontiers in Immunology·Maria Teresa MasucciMaria Vincenza Carriero
Jul 20, 2021·Seminars in Cancer Biology·Leonardo CristinzianoMaria Rosaria Galdiero

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Methods Mentioned

BETA
biopsy
ELISA
antisense oligonucleotides

Software Mentioned

SPSS
MedCalc

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