Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing

Open Forum Infectious Diseases
Rebekah M MartinKimberly E Hanson

Abstract

Targeted molecular diagnostic tests and accurate immunoassays have transformed the landscape of clinical virology, calling into question the usefulness of traditional viral culture. Here we present a case where viral culture, followed by metagenomic sequencing, was central to the diagnosis of an unexpected viral infection, with significant clinical and public health implications.

References

Oct 1, 1991·Biologicals : Journal of the International Association of Biological Standardization·R SchuurmanC Sol
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Michael Lane, Vincent A Fulginiti
Feb 12, 2004·JAMA : the Journal of the American Medical Association·Vinaya GardeMary P Fairchok
Jan 16, 2007·Clinical Microbiology Reviews·Diane S Leland, Christine C Ginocchio
Jun 10, 2010·Drug Design, Development and Therapy·Aysegul Nalca, Elizabeth E Zumbrun
Apr 8, 2011·Emerging Infectious Diseases·Gregory E YoungDebra Blog
Apr 8, 2011·Emerging Infectious Diseases·Christine M HughesInger K Damon
Jan 1, 2010·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Georg PauliCarl-Heinz Wirsing von König
Feb 1, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer L ReedMike Bray
Oct 12, 2012·Journal of Clinical Microbiology·Richard L Hodinka
Nov 14, 2014·Journal of Clinical Microbiology·Eileen M Burd
Mar 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dinesh VermaSankar Swaminathan
Nov 14, 2019·The New England Journal of Medicine·Phillip R PittmanPaul Chaplin

❮ Previous
Next ❯

Datasets Mentioned

BETA
AY313847

Methods Mentioned

BETA
nucleic acid amplification
electron microscopy

Software Mentioned

IDbyDNA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.