Contactin-1 (CNTN-1) overexpression is correlated with advanced clinical stage and lymph node metastasis in oesophageal squamous cell carcinomas

Japanese Journal of Clinical Oncology
Pengfei LiuShuyu Zhang

Abstract

Oesophageal squamous cell carcinoma is one of the deadliest malignancies worldwide. Contactin-1, a neural adhesion molecule, is implicated in tumour invasion and metastasis. The purpose of this study was to investigate the expression of CNTN-1 in normal and cancerous oesophageal tissue, and the potential relevance to clinicopathological features. Thirty normal oesophageal tissue samples and 82 primary oesophageal squamous cell carcinoma tissue samples were included in this study. The expression levels of CNTN-1, VEGF-C and HIF-1α messenger RNA were determined using reverse transcriptase-polymerase chain reaction and quantitative real-time polymerase chain reaction. The expression of the CNTN-1 protein was measured using immunohistochemistry. The expression of CNTN-1 messenger RNA was significantly increased in the tumour tissue compared with the normal oesophageal tissue (P=0.001). The oesophageal squamous cell carcinoma tissue consistently showed higher CNTN-1 protein levels. The CNTN-1 expression correlated with the oesophageal squamous cell carcinoma stage (P=0.006), lymph node metastasis (P=0.018) and lymphatic invasion (P=0.035). The messenger RNA level of CNTN-1 correlated significantly with those of VEGF-C and HIF-1α. Th...Continue Reading

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Citations

May 12, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ruijie ZhangJianping Xu
Jul 23, 2013·PloS One·Varisa PongrakhananonPithi Chanvorachote
Apr 23, 2013·Biochemical and Biophysical Research Communications·Daisuke FujiwaraYoshiaki Kajiyama
Sep 12, 2015·World Journal of Gastroenterology : WJG·De-Hu ChenBo-Jian Jiang
Oct 27, 2020·Cancer Biomarkers : Section a of Disease Markers·Guangyao LiJianyu Zhu
Nov 17, 2020·Frontiers in Oncology·Yumei LiangHaining Zhang

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