Contacts between serotoninergic fibres and dorsal horn spinocerebellar tract neurons in the cat and rat: a confocal microscopic study

Neuroscience
E JankowskaA Dahlström

Abstract

Contacts between serotoninergic nerve fibres and dorsal horn dorsal spinocerebellar tract neurons were analysed in order to investigate the morphological basis of actions of serotonin upon dorsal spinocerebellar tract neurons. In a series of experiments dorsal spinocerebellar tract neurons were labelled with intracellularly injected rhodamine-dextran in the cat. The neurons were monosynaptically excited by group II muscle afferents and cutaneous afferents and were identified by antidromic activation following stimuli applied in the cerebellum. In the second series of experiments dorsal spinocerebellar tract neurons were labelled by retrograde transport of Fluorogold injected into the cerebellum in the rat. In both series, serotoninergic fibres were labelled by using a specific anti-serotonin antiserum and were revealed by immunofluorescence. Appositions between the serotoninergic fibres and the cells were inspected with a dual channel confocal microscope. The merged images obtained with the two channels of the microscope were viewed in single optical planes 2 microns apart and in rotated three-dimensional reconstructions. Serotoninergic nerve fibres were found in apposition to cell bodies of all feline dorsal spinocerebellar tr...Continue Reading

References

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Citations

Jul 1, 1997·The European Journal of Neuroscience·E JankowskaX K Yin
Jan 25, 2002·The Journal of Comparative Neurology·Ingela Hammar, David J Maxwell
Feb 15, 2008·The Journal of Comparative Neurology·João Manuel Braz, Allan I Basbaum
Nov 15, 2003·Journal of Neurophysiology·G BoscoR E Poppele
Oct 27, 2012·Journal of Neurophysiology·Brent FedirchukHans Hultborn

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