Containment of tumor-colonizing bacteria by host neutrophils

Cancer Research
Kathrin WestphalSiegfried Weiss

Abstract

Administration of facultative anaerobic bacteria like Salmonella typhimurium, Shigella flexneri, and Escherichia coli to tumor-bearing mice leads to a preferential accumulation and proliferation of the microorganisms within the solid tumor. Until now, all known tumor-targeting bacteria have shown poor dissemination inside the tumors. They accumulate almost exclusively in large necrotic areas and spare a rim of viable tumor cells. Interestingly, the bacteria-containing necrotic region is separated from viable tumor cells by a barrier of host neutrophils that have immigrated into the tumor. We here report that depletion of host neutrophils results in a noticeably higher total number of bacteria in the tumor and that bacteria were now also able to migrate into vital tumor tissue. Most remarkably, an increase in the size of the necrosis was observed, and complete eradication of established tumors could be observed under these conditions. Thus, bacteria-mediated tumor therapy can be amplified by depletion of host neutrophils.

Citations

Jun 8, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sara Leschner, Siegfried Weiss
Jun 15, 2011·Applied Microbiology and Biotechnology·Che-Hsin LeeAi-Li Shiau
Nov 29, 2011·Applied Microbiology and Biotechnology·Che-Hsin Lee
Aug 8, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sheng-Nan JiangJung-Joon Min
Oct 15, 2010·Nature Reviews. Cancer·Neil S Forbes
Dec 6, 2011·Nucleic Acids Research·Sara LeschnerSiegfried Weiss
May 16, 2015·Biotechnology and Bioengineering·Dana N ThornlowNeil S Forbes
Dec 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Miaomin Zhang, Neil S Forbes
Jun 13, 2015·Current Opinion in Biotechnology·Carlos Piñero-LambeaLuis Ángel Fernández
Dec 20, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei ShiJian-Dong Huang
Jun 16, 2010·International Journal of Medical Microbiology : IJMM·Jochen StritzkerAladar A Szalay
Feb 24, 2009·Trends in Biochemical Sciences·Damian F Brennan, David Barford
Sep 2, 2008·Current Opinion in Biotechnology·Adam T St JeanNeil S Forbes
Apr 7, 2016·International Journal of Microbiology·Sebastian FelgnerSiegfried Weiss
Apr 22, 2011·Cellular Microbiology·Katja CrullSiegfried Weiss
Jan 21, 2014·Microbiology and Immunology·Seong Young KwonJung-Joon Min
Apr 15, 2014·Journal of Internal Medicine·V PawarS Weiss
Sep 18, 2014·Microbial Biotechnology·Beatriz Mesa-PereiraEduardo Santero
Apr 15, 2015·International Journal of Cancer. Journal International Du Cancer·Christian SternSiegfried Weiss
May 1, 2012·Microbes and Infection·Uliana KomorSusanne Häussler
May 18, 2016·International Journal of Microbiology·Cheng-Zhi WangAbraham Eisenstark
Apr 19, 2011·Current Opinion in Biotechnology·Robert M Hoffman
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Farhadul IslamJahan Ara Khanam
Apr 9, 2015·Therapeutic Delivery·Nele Van DesselNeil S Forbes
May 22, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Panos LehouritisMark Tangney
May 14, 2016·PloS One·Igor V DeynekoSiegfried Weiss
Oct 12, 2011·Experimental Biology and Medicine·Katja Crull, Siegfried Weiss
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Khaled SeidiNosratollah Zarghami
Feb 24, 2018·Frontiers in Microbiology·M Gabriela KramerRobert M Hoffman
Dec 24, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Bhushan J Toley, Neil S Forbes
Dec 13, 2019·Experimental & Molecular Medicine·Mai Thi-Quynh DuongJung-Joon Min

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