PMID: 9450713Feb 5, 1998Paper

Contamination of poliovirus vaccines with simian virus 40 (1955-1963) and subsequent cancer rates

JAMA : the Journal of the American Medical Association
H D StricklerJ J Goedert

Abstract

Poliovirus vaccine contaminated with live simian virus 40 (SV40), a macaque polyomavirus that is tumorigenic in rodents, was used extensively in the United States between 1955 and 1963. Simian virus 40 DNA has recently been detected in several rare human tumors, including ependymomas, osteosarcomas, and mesotheliomas. To determine the risk of ependymoma, osteosarcoma, and mesothelioma among Americans who as children received SV40-contaminated poliovirus vaccine. Retrospective cohort study using data from the Surveillance, Epidemiology, and End Results program (1973-1993) and the Connecticut Tumor Registry (1950-1969), as well as national mortality statistics (1947-1973). United States. Birth cohorts that were likely to have received SV40-contaminated poliovirus vaccine as infants, born 1956 through 1962 (60 811730 person-years of observation); as children, born 1947 through 1952 (46430953 person-years); or that were unexposed, born 1964 through 1969 (44959979 person-years). Relative risk (RR) of each cancer among exposed compared with unexposed birth cohorts. Age-specific cancer rates were generally low and were not significantly elevated in birth cohorts exposed to SV40-contaminated vaccine. Specifically, compared with the une...Continue Reading

Citations

Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J A Blaho, S A Aaronson
May 27, 1999·Thorax·C MulateroR M Rudd
Jan 9, 2001·Clinical Microbiology Reviews·R S BonevaL E Chapman
Jul 20, 2004·Clinical Microbiology Reviews·Regis A Vilchez, Janet S Butel
Feb 11, 2005·Molecular Medicine·Cristina MorelliMauro Tognon
Nov 13, 2008·Cytotechnology·J C Petricciani
Oct 1, 2011·Chinese Journal of Cancer·Yuan YaoMichael D Taylor
Feb 22, 2013·International Journal of Oncology·Hidenori ShirahaMasayoshi Namba
Mar 8, 2008·ILAR Journal·Lynn M Wachtman, Keith G Mansfield
Aug 7, 2007·Occupational Medicine·Malcolm J PriceJohn T Hodgson
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Eric A EngelsKeerti V Shah
Jan 10, 2001·Current Opinion in Neurology·F G Davis, B J McCarthy
Mar 31, 2000·Current Opinion in Pulmonary Medicine·A M Boylan
Jun 12, 2002·Current Treatment Options in Oncology·B W Loggie
Mar 22, 2002·Nature Reviews. Immunology·C B Wilson, E K Marcuse
Jul 17, 1999·The Journal of Legal Medicine·M R Goldman, M J Brock
Jun 6, 2003·The Cancer Journal·Kenneth D AldapeMargaret Wrensch
Dec 11, 2013·Infectious Agents and Cancer·Kenneth AlibekSamal Zhussupbekova
Aug 24, 2012·Expert Review of Vaccines·Candice Yuen-Yue Chan, Paul Anantharajah Tambyah
Oct 30, 2004·Annals of Medicine·Roumiana S Boneva, Thomas M Folks
Jul 10, 2012·Current Opinion in Virology·Janet S Butel
Nov 24, 2004·Thoracic Surgery Clinics·Raphael Bueno, Gavin J Gordon
Nov 24, 2004·Thoracic Surgery Clinics·Lambros Zellos, David C Christiani
Nov 24, 2004·Thoracic Surgery Clinics·Harvey I PassMichele Carbone
Oct 30, 2007·Neurologic Clinics·James L FisherJoseph L Wiemels
May 8, 2007·Critical Reviews in Oncology/hematology·Michele ReniCharles Vecht
Nov 5, 2003·Biotechnology and Bioengineering·Christine R ValeraYuan Xu
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·Kristina KjaerheimMichael Pawlita
Sep 24, 2004·Drug Discovery Today·Derek T O'Hagan, Rino Rappuoli
May 9, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Timothy FountaineAndrew J J Law
Nov 7, 1998·The Journal of Thoracic and Cardiovascular Surgery·H I PassM Carbone
Apr 17, 2001·Infectious Disease Clinics of North America·R T ChenB Hibbs
Dec 21, 2012·The Journal of General Virology·Mariet C W FeltkampAlexander E Gorbalenya
May 17, 2011·Vaccine·Shasta D McClenahanChristine Uhlenhaut
Oct 1, 2003·Virology·P MinorG Dunn
Feb 1, 2000·Biologicals : Journal of the International Association of Biological Standardization·L ShiY Xu
Aug 12, 1999·Biologicals : Journal of the International Association of Biological Standardization·D SangarP D Minor

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