Contemporary genomic approaches in the diagnosis and typing of Staphylococcus aureus

Pathology
D A WilliamsonGraeme R Nimmo

Abstract

Staphylococcus aureus is a major human pathogen, causing disease in both community and healthcare settings. Over the past two decades, the epidemiology of S. aureus disease has changed dramatically, with the emergence and spread of community-associated methicillin-resistant S. aureus clones. This epidemiological shift, coupled with the association between delayed antimicrobial therapy and increased mortality in S. aureus bacteraemia, has greatly facilitated advances in the rapid molecular diagnosis of S. aureus. Rapid molecular testing for S. aureus can greatly reduce laboratory turnaround time, and in some circumstances, may lead to improved clinical outcomes. In addition, advances in DNA sequencing technology and bioinformatic analysis have shed new lights on the molecular epidemiology and transmission dynamics of S. aureus. In this context, we provide an overview of the key advances in the molecular diagnosis and typing of S. aureus, with a particular focus on the clinical impact and utility of genomic technologies.

References

Aug 26, 1998·The New England Journal of Medicine·F D Lowy
Jan 9, 1999·The New England Journal of Medicine·S BlotF Colardyn
May 27, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas P LodiseMichael J Rybak
May 1, 1964·Journal of Clinical Pathology·M P JEVONS, M T PARKER
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Matthew T G HoldenJulian Parkhill
Sep 13, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S Monecke, R Ehricht
Feb 4, 2006·Journal of Clinical Microbiology·M Aires-de-SousaW Witte
Apr 13, 2007·Journal of Clinical Microbiology·Patrice FrancoisJacques Schrenzel
Nov 23, 2007·Journal of Clinical Microbiology·B StrommengerW Witte
May 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W Boucher, G Ralph Corey
May 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rachel J Gordon, Franklin D Lowy
May 30, 2008·FEMS Immunology and Medical Microbiology·Stefan MoneckeRalf Ehricht
Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ulrich NübelMark Achtman
Jul 14, 2009·Journal of Bacteriology·Raymond RuimyEdward J Feil
Dec 3, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G L French
Mar 9, 2010·Lancet·Frank R DeLeoHenry F Chambers
Apr 3, 2010·British Medical Bulletin·Fiona J Cooke, Nicholas M Brown
Aug 10, 2010·Nursing for Women's Health·Janis R Guilbeau, Lisa P Broussard
Oct 16, 2010·The Journal of Antimicrobial Chemotherapy·Mical PaulLeonard Leibovici
Dec 18, 2010·International Journal of Antimicrobial Agents·Stephan HarbarthMarc J Struelens
Oct 28, 2011·American Journal of Clinical Pathology·David H SpencerCarey-Ann D Burnham
Nov 15, 2011·Journal of Clinical Microbiology·Abigail M FryeMargret Oethinger
Apr 12, 2012·Clinical Microbiology Reviews·Sebastian J van HalIain B Gosbell
Jun 1, 2012·Critical Care : the Official Journal of the Critical Care Forum·Arash AfshariStephan Harbarth
Aug 8, 2012·Nature Reviews. Genetics·Xavier DidelotDerrick W Crook
Aug 15, 2012·Antimicrobial Agents and Chemotherapy·Stefan MoneckeRalf Ehricht
Nov 21, 2012·The Journal of Hospital Infection·J R PriceJ Paul
Jan 22, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J PriceJ Paul
Feb 13, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K B Laupland

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Citations

Sep 15, 2016·Expert Review of Anti-infective Therapy·Stefano G GiulieriBenjamin P Howden
Jun 24, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F Tagini, G Greub
Nov 9, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Pete KinrossUNKNOWN The European Human LA-Mrsa Study Group
Jan 9, 2020·Microbial Genomics·Stefano G GiulieriDeborah A Williamson

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