Contemporary radical cystectomy outcomes in patients with invasive bladder cancer: a population-based study

BJU International
Manish I PatelDavid Paul Smith

Abstract

To determine the contemporary survival outcomes from a whole population and identify significant predictors of survival, as contemporary population-based survival outcomes after radical cystectomy (RC) for the treatment of bladder cancer (BC) are sparse. Reports suggest a large disparity between population outcomes and those of centres of excellence. All invasive BC cases diagnosed between 2001 and 2007 in New South Wales, Australia, were identified from the Central Cancer Registry. Records of treatment and death were electronically linked. All patients who underwent RC between 2001 and 2009 were selected for this study (804 patients). Follow-up was to the end of 2009. Outcomes assessed were disease-specific survival (DSS) and overall survival (OS). Multivariable Cox regression and log-rank analysis were used to model and compare survival within groups. Of 804 patients diagnosed during the study period 420 (52.2%) died during follow-up. The 5-year DSS and OS for all patients was 59.6% and 53.2%, respectively. The 5-year DSS for patients with localised, regional and distant disease, undergoing RC was 72%, 51% and 10%, respectively. Age (P < 0.001) and stage (P < 0.001) were associated with 5-year DSS and OS after adjusting for a...Continue Reading

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Citations

Aug 31, 2017·Acta Oncologica·Jihane BoustaniUNKNOWN Retrospective International Study of Cancers of the Urothelial Tract (RISC) Investigators
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Oct 3, 2018·ANZ Journal of Surgery·Manish I Patel, David Gillatt
May 26, 2017·BJU International·Cristian UdovicichDaniel Lenaghan
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Feb 23, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·F Slevin, A M Henry
Apr 6, 2021·Indian Journal of Surgical Oncology·Brusabhanu NayakAmlesh Seth

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