Contemporary Review of Peyronie's Disease Treatment

Current Urology Reports
Edward Capoccia, L A Levine

Abstract

To analyze the literature on the current treatment options for Peyronie's disease (PD). Intracavernosal injection therapy using collagenase clostridium histolyticum (CCH) has been widely adopted since its FDA approval in 2013. Based on the current evidence, it appears to be moderately efficacious for men with mild curvatures. Although a recent study has shown similar outcomes using a modified protocol requiring fewer injections, CCH remains an expensive medication. Surgery provides the most definitive treatment. The most common adverse effect following surgery is perceived loss of length. Length restoration procedures have recently been developed to address this with promising results reported in small series. There are a variety of medical treatment options for PD, with CCH getting the most attention for being the first drug to be FDA approved for PD treatment. It is the authors' opinion that the non-surgical therapy most likely to provide meaningful results is combination therapy utilizing oral, intralesional, and external traction therapy. Surgery remains the gold standard for definitive treatment.

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Citations

Apr 27, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Ayman Abdelmaksoud, Mohamad Goldust
Jul 11, 2020·The World Journal of Men's Health·Fabrizio Di MaidaAndrea Cocci
Apr 9, 2019·Therapeutic Advances in Urology·Robert ValenzuelaJoel Hillelsohn
Jan 22, 2021·Urology·Quinn C RainerThomas A Masterson
Feb 19, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·G de SallmardJ-E Terrier
Jul 15, 2020·Sexual Medicine Reviews·Edward J ChoiFaysal A Yafi
Aug 28, 2021·Communications Biology·Laura Martinez-VidalMassimo Alfano

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