Contemporary role of lymph node dissection at the time of radical nephroureterectomy for upper tract urothelial carcinoma

World Journal of Urology
Thomas SeisenMorgan Rouprêt

Abstract

To review the contemporary data on the role of lymph node dissection (LND) at the time of radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). A computerized bibliographic search using the following protocol ("Nephroureterectomy") AND ("Lymphadenectomy" OR "Lymph node" OR "Lymphatic") was performed in MEDLINE to identify all original and review articles that addressed the role of LND for UTUC. Regional lymph node (LN) boundaries of UTUC have been recently investigated in mapping studies to propose anatomic templates of LND according to the laterality and location of primary tumor. Although these anatomic templates remained poorly described, most reports supported the staging benefit of LND that allowed for risk stratification of patients with (pN+) or without (pN0) LN metastases from those who did not undergo such a procedure (pNx). In addition, the therapeutic benefit of LND at the time of RNU was supported by better oncological outcomes obtained after complete LND when compared to incomplete or no LND, especially in the group of patients with advanced disease. The number of LNs removed was also correlated with both, more accurate staging and greater cancer-specific survival after LND, whose feasibilit...Continue Reading

References

Jan 4, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Fernando P SecinBernard H Bochner
Jul 14, 2010·The Journal of Urology·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma Collaborative Group
Sep 4, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Tsunenori KondoKazunari Tanabe
Sep 14, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T AbeK Nonomura
Jul 30, 2011·European Urology·Marco RoscignoRichard Zigeuner
Apr 21, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Tsunenori Kondo, Kazunari Tanabe
Mar 29, 2014·Expert Review of Anticancer Therapy·Deyong YangLina Wang
Feb 25, 2015·Nature Reviews. Urology·Thomas SeisenMorgan Rouprêt
Jun 23, 2015·The Journal of Urology·Surena F MatinPhilippe E Spiess

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Citations

May 5, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas SeisenSteven Lee Chang
May 5, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bivas BiswasDeepak Dabkara
Mar 3, 2017·World Journal of Urology·Avinash NehraAlberto Briganti
Apr 3, 2019·Current Treatment Options in Oncology·Mounsif AziziPhilippe E Spiess
Oct 14, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Subo QianHaibo Shen

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