Contemporary Strategies and Barriers to Transplantation Tolerance

Transplantation
Brian EzekianStuart J Knechtle

Abstract

The purpose of this review is to discuss immunologic tolerance as it applies to solid organ transplantation and to identify barriers that hinder the achievement of this long-term goal. First, the definition of tolerance and an introduction of mechanisms by which tolerance exists or can be achieved will be discussed. Next, a review of contemporary attempts at achieving transplant tolerance will be described. Finally, a discussion of the humoral barriers to transplantation tolerance and potential ways to overcome these barriers will be presented.

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Citations

Mar 22, 2019·Transplantation·Franka MessnerGerald Brandacher
Feb 20, 2020·Current Opinion in Organ Transplantation·Lillian Tran, Abhinav Humar
Jul 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shuangjin YuXunrong Luo
Sep 21, 2019·Immunological Reviews·Shuangjin YuXunrong Luo
Mar 25, 2019·Frontiers in Immunology·Govindarajan Thangavelu, Bruce R Blazar
Jun 17, 2020·Transplantation·Song C Ong, Robert S Gaston
Mar 16, 2021·Frontiers in Immunology·Irma Husain, Xunrong Luo
Jan 9, 2021·Transplantation·Xinle WangCatia T Perciani
Jun 4, 2019·Current Opinion in Organ Transplantation·Paul M SchroderStuart J Knechtle

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Methods Mentioned

BETA
biopsies
xenograft
gene-knockout
intragraft

Software Mentioned

ONE

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