Content and redistribution of vitamin E in tissues of Wistar rats under oxidative stress induced by hydrazine

Archives of Environmental Contamination and Toxicology
J AntosiewiczJ Popinigis

Abstract

Hydrazine toxicity is associated with generation of several kinds of free radicals and oxidative stress in cell. Experiments in vivo have demonstrated that oxidative stress could either diminish or increase concentration of vitamin E in some tissues. Thus in the present study we performed experiments to determine whether hydrazine-induced oxidative stress would change the tissue levels of the vitamin. Seven days of hydrazine intoxication led to accumulation of different amounts of vitamin E: 215% in the liver, 118% in the heart, 135% in the spleen, and 100% in the muscle over control value. There were no changes in the level of the vitamin in kidney and pancreas, despite its significant depletion in the serum. In tissue that accumulated vitamin E after hydrazine treatment, an increased of oxidative stress measured by the concentration of lipid-soluble fluorophore was observed. Significant increases of 107%, 46%, 72%, and 58% over control values were observed in the liver, heart, spleen, and muscle, respectively. Rats treated with hydrazine and pharmacological doses of alpha-tocopherol accumulated higher concentrations of vitamin E in all studied tissues compared with the alpha-tocopherol-only treated rats. However, in tissues w...Continue Reading

Citations

Dec 11, 2008·Archives of Toxicology·Chinatsu IidaShosuke Kojo
Apr 3, 2009·The Journal of Physiological Sciences : JPS·Barbara KłapcińskaJózef Langfort
Nov 28, 2006·Biochemistry. Biokhimii︠a︡·V MoulisováA Jegorov
Dec 23, 2003·Human & Experimental Toxicology·Christina E Schwab, Helga Tuschl
Dec 7, 2019·Progress in Lipid Research·Paul L Else

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