Content of circulating extracellular DNA, plasma activities of matrix metalloproteinases, and ultrastructure of the myocardium in hypothyroid rats with hypercholesterolemia

Bulletin of Experimental Biology and Medicine
L P PolyakovV I Pichigin

Abstract

Free circulating extracellular DNA, plasma activities of matrix metalloproteinases in hypothyroid rats, and ultrastructural changes in the myocardium were studied under conditions of experimental hypercholesterolemia. For suppression of thyroid function, the animals received antithyroid drug mercazolyl under conditions of cholesterol diet. Hypercholesterolemia in hypothyroid rats (thyroxine concentration 2-fold below the normal) was paralleled by a pronounced increase of the concentration of free circulating extracellular DNA and total matrix metalloproteinases 2 and 7 activity. These changes were associated with lytic and destructive changes in cardiomyocytes and blood capillary endotheliocytes. Changes in the cardiomyocyte and endotheliocyte ultrastructure were more pronounced in hypothyroid rats.

References

Jul 27, 1999·The Journal of Biological Chemistry·H Nagase, J F Woessner
Jan 7, 2004·Analytical Biochemistry·Evgeniy S MorozkinValentin V Vlassov
Aug 30, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yu-Kwan Tong, Y M Dennis Lo
Feb 9, 2010·Cardiovascular Research·Helen WilliamsSarah J George
Mar 1, 2011·Cardiovascular Research·Gerrit J ReimersKenneth J Rodgers
May 10, 2013·Bulletin of Experimental Biology and Medicine·D V SumenkovaL E Panin
Apr 29, 2014·Bulletin of Experimental Biology and Medicine·E L LushnikovaV I Pichigin

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