Context-dependent genetic architecture of Drosophila life span.

PLoS Biology
Wen HuangTrudy F C Mackay

Abstract

Understanding the genetic basis of variation in life span is a major challenge that is difficult to address in human populations. Evolutionary theory predicts that alleles affecting natural variation in life span will have properties that enable them to persist in populations at intermediate frequencies, such as late-life-specific deleterious effects, antagonistic pleiotropic effects on early and late-age fitness components, and/or sex- and environment-specific or antagonistic effects. Here, we quantified variation in life span in males and females reared in 3 thermal environments for the sequenced, inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) and an advanced intercross outbred population derived from a subset of DGRP lines. Quantitative genetic analyses of life span and the micro-environmental variance of life span in the DGRP revealed significant genetic variance for both traits within each sex and environment, as well as significant genotype-by-sex interaction (GSI) and genotype-by-environment interaction (GEI). Genome-wide association (GWA) mapping in both populations implicates over 2,000 candidate genes with sex- and environment-specific or antagonistic pleiotropic allelic effects. Over 1,000...Continue Reading

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Citations

Jan 24, 2020·G3 : Genes - Genomes - Genetics·Grace A ParkerTrudy F C Mackay
Dec 17, 2020·American Journal of Human Genetics·Andrew R MardersteinAndrew G Clark
Mar 27, 2021·Evolutionary Applications·Ary A HoffmannAndrew R Weeks
Mar 8, 2021·G3 : Genes - Genomes - Genetics·Cory A WellerAlan O Bergland
Jun 3, 2021·Insects·Palle Duun RohdeTorsten Nygaard Kristensen
Aug 8, 2021·American Journal of Human Genetics·Andrew R MardersteinOlivier Elemento
Aug 31, 2021·Royal Society Open Science·Jessica M HoffmanSteven N Austad
May 27, 2021·Genome Research·Brandon M BakerRobert R H Anholt

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Datasets Mentioned

BETA
PRJNA577841

Methods Mentioned

BETA
chip

Software Mentioned

MEM
GATK
BWA
CASAVA
RTA

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