Context-driven cocaine-seeking in abstinent rats increases activity-regulated gene expression in the basolateral amygdala and dorsal hippocampus differentially following short and long periods of abstinence.

Neuroscience
M C HearingJ F McGinty

Abstract

In this study, the expression patterns of zif268 and activity-regulated cytoskeleton-associated gene (arc) were investigated in the basolateral amygdala (BLA) and dorsal hippocampal (dHPC) subregions during context-induced drug-seeking following 22 h or 15 d abstinence from cocaine self-administration. Arc and zif/268 mRNA in BLA and dHPC increased after re-exposure to the cocaine-paired chamber at both timepoints; however, only the BLA increases (with one exception-see below) were differentially affected by the presence or absence of the cocaine-paired lever in the chamber. Following 22 h of abstinence, arc mRNA was significantly increased in the BLA of cocaine-treated rats re-exposed to the chamber only with levers extended, whereas following 15 d of abstinence, arc mRNA in the BLA was increased in cocaine-treated rats returned to the chamber with or without levers extended. In contrast, zif268 mRNA in the BLA was greater in cocaine-treated rats returned to the chamber with levers extended vs. levers retracted only after 15 d of abstinence. In the dentate gyrus (DG) following 22 h of abstinence, zif268 mRNA was greater in rats returned to the chamber where levers were absent regardless of drug treatment whereas arc mRNA was i...Continue Reading

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Citations

Sep 10, 2013·Neurobiology of Learning and Memory·Akash GautamMahendra K Thakur
Aug 3, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M OtisDevin Mueller
Sep 17, 2014·Neurobiology of Learning and Memory·Yasaman AlaghbandJohn F Marshall
Sep 29, 2011·Neurobiology of Learning and Memory·Morgan LucasCatherine Le Moine
Apr 28, 2016·Neuroscience and Biobehavioral Reviews·Estela Castilla-OrtegaLuis J Santín
Sep 22, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew G CrowsonDebara Tucci

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