Context-induced relapse of conditioned behavioral responding to ethanol cues in rats.

Biological Psychiatry
Nadia ChaudhriPatricia H Janak

Abstract

The environmental context in which drug-conditioned cues are encountered could modulate the capacity of such cues to trigger relapse in abstinent addicts. We explored this hypothesis using a behavioral animal model. Rats were trained to discriminate between two auditory stimuli; the first (CS+) was paired with 10% ethanol and the second (CS-) was presented without ethanol. Training occurred in operant conditioning chambers equipped with distinct contextual stimuli, and entries into the ethanol delivery port during the stimuli were measured. Behavior was then extinguished by presenting both stimuli without ethanol in a second, different context. Context-dependent renewal of port entries was tested by presenting the CS+ and CS- without ethanol in the original training context. At test, port entries during the CS+ increased compared with extinction levels, while responding during the CS- remained unchanged (n = 11). This effect was attenuated after multiple extinction sessions in three distinct contexts (n = 18), compared with an equivalent number of extinction sessions in a single unique context (n = 16). Context-dependent renewal of port entries was also observed to a CS+ paired with 14% sucrose (n = 7) but not to a CS+ paired w...Continue Reading

References

Jan 1, 1992·Addictive Behaviors·R Hammersley
Jan 1, 1986·Addictive Behaviors·A M Ludwig
Dec 1, 1993·Journal of Consulting and Clinical Psychology·P M MontiD B Abrams
Feb 28, 1996·JAMA : the Journal of the American Medical Association·P A NuttingS Holcomb
Dec 1, 1996·Physiology & Behavior·K GillB R Smith
Jun 5, 1998·Behaviour Research and Therapy·L M GuntherR R Miller
Dec 22, 1999·Addiction·B L Carter, S T Tiffany
Nov 3, 2001·Brain Research. Brain Research Reviews·B J EverittT W Robbins
Feb 28, 2002·Addiction·Cynthia A Conklin, Stephen T Tiffany
Mar 16, 2002·Behavioral Neuroscience·Hans S Crombag, Yavin Shaham
Dec 5, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hans S CrombagYavin Shaham
Mar 30, 2004·Nature Neuroscience·Roberto CiccocioppoFriedbert Weiss
Oct 7, 2004·Learning & Memory·Mark E Bouton
Oct 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rita A FuchsRonald E See
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M BossertYavin Shaham
Jan 22, 2005·Current Opinion in Pharmacology·Friedbert Weiss
Oct 4, 2005·Behaviour Research and Therapy·Mark E BoutonErik W Moody
Nov 1, 2005·Behavioural Brain Research·Isabella ZironiPatricia H Janak
Mar 1, 2006·Experimental and Clinical Psychopharmacology·Cynthia A Conklin
Apr 18, 2006·Biological Psychiatry·Mark E BoutonStephen Maren
Feb 14, 2007·Alcoholism, Clinical and Experimental Research·Helen C FoxRajita Sinha
Mar 24, 2007·Alcoholism, Clinical and Experimental Research·Laura H Corbit, Patricia H Janak

❮ Previous
Next ❯

Citations

May 29, 2012·Psychopharmacology·Mary M Torregrossa, Jane R Taylor
Nov 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nadia ChaudhriPatricia H Janak
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karyn M MyersMichael Davis
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hans S CrombagYavin Shaham
Jan 13, 2011·Learning & Memory·Patricia H Janak, Laura H Corbit
Aug 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary M TorregrossaJane R Taylor
Mar 19, 2014·Psychopharmacology·Joshua A Peck, Robert Ranaldi
Mar 5, 2013·Computer Methods and Programs in Biomedicine·Esther MondragónJonathan Gray
Apr 23, 2014·British Journal of Pharmacology·Christina J PerryAndrew J Lawrence
May 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joanna M SciasciaNadia Chaudhri
Mar 19, 2015·Frontiers in Behavioral Neuroscience·Chandra S SreyNadia Chaudhri
May 17, 2011·Biological Psychiatry·Claudia MihindouSerge H Ahmed
Jan 30, 2010·Neuroscience and Biobehavioral Reviews·Karyn M Myers, William A Carlezon
Dec 25, 2016·Psychopharmacology·Jean-Marie N Maddux, Nadia Chaudhri
Nov 12, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Franca LacroixNadia Chaudhri
Oct 30, 2013·Alcoholism, Clinical and Experimental Research·Joanna M SciasciaNadia Chaudhri
May 21, 2018·The European Journal of Neuroscience·Jennifer M BossertYavin Shaham
Apr 4, 2016·Alcoholism, Clinical and Experimental Research·Christopher P KnightZachary A Rodd
Mar 3, 2020·Frontiers in Behavioral Neuroscience·Shaun Yon-Seng KhooNadia Chaudhri
Jan 19, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Paula Alejandra NavarroWilliam Omar Contreras López
Sep 25, 2020·Physiological Reviews·Mark E BoutonGavan P McNally
Feb 6, 2021·Behavioural Processes·Joseph A Lutz, Emma Childs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.