Context-specific tolerance to the ataxic effects of alcohol

Pharmacology, Biochemistry, and Behavior
Aaron M WhitePhillip J Best

Abstract

Tolerance to alcohol and many other drugs can become conditioned to specific contextual cues present at the time of drug administration. Context-specific tolerance occurs to a variety of alcohol's effects, including changes in hormone levels, body temperature and locomotor activity. The present study investigated whether context-specific tolerance can occur to the ataxic effects of alcohol. Baseline levels of motor coordination were assessed using a tilting plane apparatus. During a 7-day tolerance acquisition phase, subjects received an injection of either alcohol (1.5 g/kg i.p.) or saline (15 ml/kg i.p.) in a novel testing room and were then placed in the tilting plane apparatus for a period of 20 min. Approximately 5 h after the first injection, subjects received a second injection in the colony room and were then placed in their home cages. One group of subjects, the paired group, received alcohol in the testing room and saline in the colony room. An unpaired group received saline in the testing room and alcohol in the colony room. A no alcohol control group received saline in both environments. Following the tolerance acquisition phase, all subjects were injected with alcohol (1.5 g/kg i.p.) and tested for ataxia in the ti...Continue Reading

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Citations

May 28, 2004·Psychopharmacology·Douglas C BrooksAmanda M Woods
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Aaron M WhiteH Scott Swartzwelder
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·L J Bertoglio, A P Carobrez
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Apr 9, 2010·Alcoholism, Clinical and Experimental Research·Ricardo M PautassiYedy Israel
Feb 6, 2021·Behavioural Processes·Joseph A Lutz, Emma Childs
Aug 16, 2005·Pharmacology, Biochemistry, and Behavior·K CroniseJ C Crabbe

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