Contiguous stereogenic quaternary carbons: a daunting challenge in natural products synthesis

Proceedings of the National Academy of Sciences of the United States of America
Emily A Peterson, Larry E Overman

Abstract

One element of structure that invariably increases the difficulty of a chemical synthesis is the presence in the target molecule of contiguous all-carbon quaternary stereocenters. This Perspective will examine the most useful transformations and strategies devised recently for directly assembling this structural unit.

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Citations

May 16, 2013·Accounts of Chemical Research·Tom MejuchIlan Marek
Apr 25, 2009·Journal of the American Chemical Society·Jorge García-FortanetStephen L Buchwald
Mar 25, 2006·The Journal of Organic Chemistry·Larry E Overman, Donald A Watson
Mar 25, 2006·The Journal of Organic Chemistry·Larry E Overman, Donald A Watson
Aug 10, 2007·The Journal of Organic Chemistry·Jibo XiaJoseph P Konopelski
Jan 3, 2012·The Journal of Organic Chemistry·Gamal A I MoustafaTakehiko Yoshimitsu
May 27, 2010·Chemical Communications : Chem Comm·Shigang WenJinxing Ye
May 20, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Saori ShirakiMiguel A Garcia-Garibay
Jan 24, 2012·Chemical Communications : Chem Comm·Xin HuangYing-Chun Chen
Jan 23, 2014·Organic Letters·Jakob Danielsson, Peter Somfai
Apr 12, 2014·Journal of the American Chemical Society·Michael J Ardolino, James P Morken
Apr 3, 2012·Drug Discoveries & Therapeutics·H X Lou
Mar 13, 2016·Natural Products and Bioprospecting·Xianfu ShenHongbin Zhang
Oct 4, 2005·Life Sciences·Marcy J Balunas, A Douglas Kinghorn
Sep 14, 2016·Journal of the American Chemical Society·Wenxin ChenGuigen Li
Feb 2, 2017·The Journal of Organic Chemistry·Anita HoangPeter Somfai
Mar 9, 2017·Chemistry : a European Journal·Xiao-Qiang LiLing Zhou
May 17, 2017·Angewandte Chemie·Juan FengYefeng Tang
May 23, 2017·Organic Letters·Nan ZhengZhen Yang

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