Continentalic acid from Aralia continentalis shows activity against methicillin-resistant Staphylococcus aureus

Phytotherapy Research : PTR
Seung-Il JeongKang-Ju Kim

Abstract

In a continuing search for compounds with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), a chloroform extract of roots of Aralia continentalis was found to contain continentalic acid (CA, C(20)H(30)O(2)), a diterpenic acid. This compound exhibited potent activity against standard methicillin-susceptible Staphylococcus aureus (MSSA) as well as clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). It was determined that continentalic acid had minimum inhibitory concentrations (MICs) of approximately 8-16 microg/mL against S. aureus, including the MSSA and MRSA standard strains. Therefore, the results obtained in this study suggest that continentalic acid might have potential as an adjunct in the treatment of antibiotic-resistant bacteria.

References

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Aug 23, 2005·Phytotherapy Research : PTR·Hi-Joon ParkSabina Lim
Sep 15, 2005·Phytotherapy Research : PTR·Kang-Ju KimYong-Ouk You

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Citations

Sep 23, 2008·Archives of Pharmacal Research·Tae Oh KwonSeon Il Jang
Nov 10, 2009·Archives of Pharmacal Research·Hyun Ah JungJae Sue Choi
Nov 23, 2007·Natural Product Reports·James R Hanson
Jul 26, 2011·Journal of Ethnopharmacology·Da-Hong LeeYong-Ouk You
Mar 14, 2020·Journal of Asian Natural Products Research·Ji Eun LeeSeong Su Hong

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