Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial

Annals of Internal Medicine
Joseph J Y SungFrancis K L Chan

Abstract

It is uncertain whether aspirin therapy should be continued after endoscopic hemostatic therapy in patients who develop peptic ulcer bleeding while receiving low-dose aspirin. To test that continuing aspirin therapy with proton-pump inhibitors after endoscopic control of ulcer bleeding was not inferior to stopping aspirin therapy, in terms of recurrent ulcer bleeding in adults with cardiovascular or cerebrovascular diseases. A parallel randomized, placebo-controlled noninferiority trial, in which both patients and clinicians were blinded to treatment assignment, was conducted from 2003 to 2006 by using computer-generated numbers in concealed envelopes. (ClinicalTrials.gov registration number: NCT00153725) A tertiary endoscopy center. Low-dose aspirin recipients with peptic ulcer bleeding. 78 patients received aspirin, 80 mg/d, and 78 received placebo for 8 weeks immediately after endoscopic therapy. All patients received a 72-hour infusion of pantoprazole followed by oral pantoprazole. All patients completed follow-up. The primary end point was recurrent ulcer bleeding within 30 days confirmed by endoscopy. Secondary end points were all-cause and specific-cause mortality in 8 weeks. 156 patients were included in an intention-to...Continue Reading

Associated Clinical Trials

Citations

Mar 25, 2014·Drugs & Aging·Moe Htet Kyaw, Francis Ka Leung Chan
Sep 21, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Hisham Al DhahabAlan Barkun
Oct 29, 2013·Journal of Pediatric Psychology·Sarah S JaserMargaret Grey
Jan 1, 2010·Drug, Healthcare and Patient Safety·Harald VonkemanMart van de Laar
Aug 19, 2011·The Journal of Pharmacology and Experimental Therapeutics·Marcus M Reidenberg
Sep 16, 2011·Current Gastroenterology Reports·Ingrid Lisanne Holster, Ernst Johan Kuipers
Apr 8, 2014·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Tevfik SolakogluOsman Ersoy
Dec 24, 2011·Thrombosis·Enma V Paez EspinosaFadi T Khasawneh
Oct 24, 2013·Medizinische Klinik, Intensivmedizin und Notfallmedizin·G Braun, H Messmann
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Muthiah Vaduganathan, Deepak L Bhatt
Jul 28, 2012·Expert Opinion on Drug Metabolism & Toxicology·Morten Würtz, Erik Lerkevang Grove
Apr 22, 2015·Hämostaseologie·K Schrör
Dec 2, 2015·Gastrointestinal Endoscopy·UNKNOWN ASGE STANDARDS OF PRACTICE COMMITTEEJohn M DeWitt
Mar 2, 2016·The American Journal of Gastroenterology·Lisa L Strate, Ian M Gralnek
Aug 3, 2012·Journal of Advanced Nursing·Elizabeth A Laird, Vivien Coates
Jan 28, 2014·Alimentary Pharmacology & Therapeutics·H MalmiM A Färkkilä
Jan 7, 2015·Nature Reviews. Gastroenterology & Hepatology·Marc BardouAlan Barkun
Jun 16, 2016·The New England Journal of Medicine·Loren Laine
Sep 29, 2011·Gastrointestinal Endoscopy Clinics of North America·Thomas O G Kovacs, Dennis M Jensen
Oct 21, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Elvira Teles-SampaioIsabel Pedroto
Nov 5, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Gema Plumé GimenoMaria José Cejalvo Andújar
Jun 14, 2013·Interactive Cardiovascular and Thoracic Surgery·Michael GorlitzerMartin Grabenwoeger
Mar 16, 2017·The New England Journal of Medicine·Ian M GralnekLisa L Strate
Jan 23, 2017·Gastroenterología y hepatología·Pilar García-IglesiasRafel Campo Fernández de Los Ríos
Nov 4, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tomoyoshi ShibuyaSumio Watanabe
Aug 15, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·María E SáezLuis A García Rodríguez
Dec 3, 2014·Gastroenterology Clinics of North America·Yidan LuAlan Barkun
Apr 2, 2017·Current Problems in Cardiology·Carl J LavieJames Tursi
Mar 1, 2017·Lancet·Angel Lanas, Francis K L Chan
Mar 9, 2017·British Journal of Haematology·Martin J ScottJecko Thachil
Dec 7, 2016·Pharmacoepidemiology and Drug Safety·Antonio González-PérezLuis A García Rodríguez
Jun 29, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Gary S Gronseth, Eric Ashman
Dec 17, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·María E SáezLuis A García Rodríguez
Nov 1, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Gary S Gronseth, Eric Ashman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.