Continuation versus discontinuation of antiplatelet therapy for bleeding and ischaemic events in adults undergoing non-cardiac surgery

The Cochrane Database of Systematic Reviews
Sharon R LewisAndrew F Smith

Abstract

Antiplatelet agents are recommended for people with myocardial infarction and acute coronary syndromes, transient ischaemic attack or stroke, and for those in whom coronary stents have been inserted. People who take antiplatelet agents are at increased risk of adverse events when undergoing non-cardiac surgery because of these indications. However, taking antiplatelet therapy also introduces risk to the person undergoing surgery because the likelihood of bleeding is increased. Discontinuing antiplatelet therapy before surgery might reduce this risk but subsequently it might make thrombotic problems, such as myocardial infarction, more likely. To compare the effects of continuation versus discontinuation for at least five days of antiplatelet therapy on the occurrence of bleeding and ischaemic events in adults undergoing non-cardiac surgery under general, spinal or regional anaesthesia. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 1), MEDLINE (1946 to January 2018), and Embase (1974 to January 2018). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. We included randomized controlled trials of adults who we...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 13, 1998·Journal of Cataract and Refractive Surgery·E I AssiaF Segev
Mar 15, 2000·The Journal of the American Dental Association·L ArdekianD Laufer
Oct 30, 2003·The Cochrane Database of Systematic Reviews·C A HawkesD Foxcroft
Nov 6, 2007·Annales de dermatologie et de vénéréologie·A DaninoS Dalac
May 6, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Apr 19, 2011·European Journal of Anaesthesiology·Anna OscarssonChristina Eintrei
Aug 2, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Frederico Buhatem MedeirosLuciano Lauria Dib
Aug 2, 2011·Journal of Clinical Epidemiology·Gordon H GuyattUNKNOWN GRADE Working Group
Nov 15, 2011·The American Journal of Medicine·Anita G AuFinlay A McAlister
Oct 9, 2013·JAMA : the Journal of the American Medical Association·Mary T HawnThomas M Maddox
Dec 18, 2013·British Journal of Anaesthesia·A D Oprea, W M Popescu
Apr 1, 2014·The New England Journal of Medicine·P J DevereauxUNKNOWN POISE-2 Investigators
May 17, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Roberta RossiniUNKNOWN Society of Ophthalmology Lombardia (SOL)
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Jul 8, 2015·The Cochrane Database of Systematic Reviews·Mathias JohansenArash Afshari
Aug 15, 2015·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·K George VargheseMohan Sadhanandan
Apr 24, 2016·British Journal of Anaesthesia·P J Devereaux, J Eikelboom
Jul 29, 2016·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Arman EnghetaMehdi Sanatkarfar
Aug 5, 2016·The Cochrane Database of Systematic Reviews·Na ZhaoYuguang Huang
Oct 8, 2016·British Journal of Haematology·David KeelingUNKNOWN British Committee of Standards for Haematology

❮ Previous
Next ❯

Citations

Sep 27, 2019·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Sep 24, 2019·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Dec 13, 2019·The Cochrane Database of Systematic Reviews·Anna WrzosekJerzy Wordliczek
Jun 4, 2020·European Journal of Anaesthesiology·Benedikt PreckelJannicke Mellin-Olsen
Jun 20, 2020·The Journal of Bone and Joint Surgery. American Volume·Antony J R PalmerGeorge Grammatopoulos
Jul 18, 2020·Anesthesia and Analgesia·Neal S GersteinPeter M Schulman
Nov 3, 2020·Frontiers in Neurology·Lorenzo MongardiAlba Scerrati
Oct 16, 2021·Internal and Emergency Medicine·Andrew Tiger ChenJames Demetrios Douketis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Related Papers

The Cochrane Database of Systematic Reviews
Jorinde Aw PoldermanJeroen Hermanides
The Cochrane Database of Systematic Reviews
Jorinde Aw PoldermanJeroen Hermanides
The Cochrane Database of Systematic Reviews
Julie Wm EgholmHanne Tønnesen
© 2022 Meta ULC. All rights reserved