Continued chemosensitivity to cisplatin/carboplatin in ovarian carcinoma despite treatment with multiple prior platinum-based regimens

Gynecologic Oncology
Maurie MarkmanJ Belinson

Abstract

While it is well recognized that individuals with ovarian cancer who have previously responded to platinum-based therapy can achieve a second response to cisplatin or carboplatin at the time of relapse, limited data exist in the oncologic literature regarding the number of times this process can be repeated. We briefly report here three patients with ovarian cancer currently being cared for in the Gynecologic Oncology program of the Cleveland Clinic Foundation who have achieved four (1 patient) or five (2 patients) separate clinical responses to cisplatin or carboplatin-based chemotherapy and have survived >4 years since the date of first relapse. This experience emphasizes the point that platinum resistance cannot be defined based on total treatment courses or the number of prior platinum-based regimens delivered, but only by objective evidence of failure of the drugs in an individual patient.

Citations

Oct 5, 2010·Metal-based Drugs·Nektaria MakriliaMuhammad Wasif Saif
Nov 15, 2006·The Journal of Obstetrics and Gynaecology Research·Aya MatsumotoShingo Fujii
May 31, 2013·Asia-Pacific Journal of Clinical Oncology·Despina HandoliasDanny Rischin
Oct 18, 2005·Gynecologic Oncology·Maurie Markman
Jun 15, 1999·Gynecologic Oncology·G H Eltabbakh, M S Piver
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurie MarkmanJerome Belinson
Oct 31, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nonna V KolomeyevskayaPeter J Frederick
Mar 4, 1998·Current Opinion in Obstetrics & Gynecology·L M Chen, J S Berek
May 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Katherine LaVigneRoisin E OʼCearbhaill

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